HYDROQUINONE

Hydroquinone is a benzenediol comprising benzene core carrying two hydroxy substituents para to each other. It has a role as an antioxidant, a cofactor, a carcinogenic agent, a mouse metabolite, a human xenobiotic metabolite, an Escherichia coli metabolite and a skin lightening agent. It is a benzenediol and a member of hydroquinones.

Source: PubChem

US FDA substance register · UNII XV74C1N1AE · registered name Hydroquinone · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Hydroquinone is the aromatic organic compound that conforms to the formula:

Banned

Argentina · Brazil · United Kingdom

Restricted or banned

Argentina · Brazil · China · South Korea

Restricted

United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · UK cosmetics regulations (OPSS) · Health Canada Cosmetic Ingredient Hotlist

ASEAN

• Field of application and/or use : Artificial nail systems
• Maximum authorised concentration in the finished cosmetic product : 0.02% after mixing for use
• Other limitations and requirements : Professional use only
• Conditions of use and warning which must be printed on the labels : • For professional use only • Avoid skin contact • Read directions for use carefully

Canada

• Conditions of Use by product type : (a) Oxidizing colouring agent for hair dyes (b) Nail products (c) Cyanoacrylate adhesive products for eyelash and eyebrow extensions
• Maximum Concentration Permitted : (a) 0.3% (b) 0.1% If hydroquinone and p-hydroxyanisole are used in the same product, the total concentration of the 2 ingredients may not exceed 0.1% (c) 0.1%
• Warnings and Cautionary Statements: (to the effect of) : (a) "Avoid skin contact", "Do not use to dye eyelashes or eyebrows", "Rinse eyes immediately if the product comes into contact with eyes" (b) "Avoid skin contact."; "Read directions carefully before using." (c) "Avoid skin contact."; "Read directions carefully before using."

European Union

• Product Type, body parts : Artificial nail systems
• Maximum concentration in ready for use preparation : 0.02% (after mixing for use)
• Other : Professional use
• Wording of conditions of use and warnings : - For professional use only - Avoid skin contact - Read directions for use carefully

Korea’s toxic-substance GHS classification: Danger · H410 (category 1) · H400 (category 1) · H351 (category 2) · +4 more

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex III (restricted substances), entry 14 · maximum concentration 0.02% (after mixing for use) · applies to Artificial nail systems

Source: EU restricted substances (Annex III)

EU Cosmetics Regulation, Annex II (prohibited substances), entry 1339

Source: EU prohibited substances (Annex II)

Restriction II/1339 III/14 · Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

Reviewed by CIR: Final Report: Amended Safety Assessment of Hydroquinone as Used in Cosmetics

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Final Report on the Safety Assessment of Hydroquinone and Pyrocatechol (Pyrocatechol has been Amended. IJT 16(S1) 11-58 1997.) (Hydroquinone has an Addendum. JACT 13(3) 167-230 1994.)

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Final Amended Safety Assessment of Hydroquinone as Used in Cosmetics

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Addendum to the Final Report on the Safety Assessment of Hydroquinone

Source: US Cosmetic Ingredient Review (CIR)