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成分词典

成分词典

HYDROQUINONE

Hydroquinone is a benzenediol comprising benzene core carrying two hydroxy substituents para to each other.

分子结构

产品中实际含有多少

暂无产品标示该成分含量。

含该成分的产品中,88 款将其列在 1% 线之前,1 款列在之后(通常不超过 1%)。

含有此成分的产品

已确认 89 款中的 12 款 · 按含量充足程度排序 · 查看全部 89 款

定义

Hydroquinone is a benzenediol comprising benzene core carrying two hydroxy substituents para to each other. It has a role as an antioxidant, a cofactor, a carcinogenic agent, a mouse metabolite, a human xenobiotic metabolite, an Escherichia coli metabolite and a skin lightening agent. It is a benzenediol and a member of hydroquinones.

来源: PubChem

美国FDA 物质登记 · UNII XV74C1N1AE · 登记名称 Hydroquinone · 单一化学物质

来源: 美国FDA 物质识别码(UNII)

Hydroquinone is the aromatic organic compound that conforms to the formula:

化妆品中的作用

延缓产品因氧化变质ANTIOXIDANT染发HAIR DYEING还原其他成分REDUCING使头发或皮肤褪色BLEACHING登记为香料组成物质(并非表示其增香)FRAGRANCE

安全与法规参考

禁用
阿根廷 · 巴西 · 英国
限用·禁用
阿根廷 · 巴西 · 韩国 · 中国
限用
英国

来源: 东盟化妆品指令 · 欧盟化妆品法规 · 韩国食药处 化妆品法规信息 · 英国化妆品法规 · 加拿大禁用·限用成分清单

东盟

  • Field of application and/or use : Artificial nail systems
  • Maximum authorised concentration in the finished cosmetic product : 0.02% after mixing for use
  • Other limitations and requirements : Professional use only
  • Conditions of use and warning which must be printed on the labels : • For professional use only • Avoid skin contact • Read directions for use carefully

加拿大

  • Conditions of Use by product type : (a) Oxidizing colouring agent for hair dyes (b) Nail products (c) Cyanoacrylate adhesive products for eyelash and eyebrow extensions
  • Maximum Concentration Permitted : (a) 0.3% (b) 0.1% If hydroquinone and p-hydroxyanisole are used in the same product, the total concentration of the 2 ingredients may not exceed 0.1% (c) 0.1%
  • Warnings and Cautionary Statements: (to the effect of) : (a) "Avoid skin contact", "Do not use to dye eyelashes or eyebrows", "Rinse eyes immediately if the product comes into contact with eyes" (b) "Avoid skin contact."; "Read directions carefully before using." (c) "Avoid skin contact."; "Read directions carefully before using."

欧盟

  • Product Type, body parts : Artificial nail systems
  • Maximum concentration in ready for use preparation : 0.02% (after mixing for use)
  • Other : Professional use
  • Wording of conditions of use and warnings : - For professional use only - Avoid skin contact - Read directions for use carefully

来源: 韩国食药处 化妆品法规信息

韩国有毒物质 GHS 分类: 危险 · H410 (第1类) · H400 (第1类) · H351 (第2类) · 另有 4 项

来源: 韩国有毒物质 GHS 信息(环境公团)

欧盟化妆品法规 附录III(限用物质) 第14项 · 最高浓度 0.02% (after mixing for use) · 适用 Artificial nail systems

来源: 欧盟限用成分(附录III)

欧盟化妆品法规 附录II(禁用物质) 第1339项

来源: 欧盟禁用成分(附录II)

Restriction II/1339 III/14 · Other restriction: ban substances that deplete the ozone layer

来源: 欧盟 CosIng 成分清单

Reviewed by CIR: Final Report: Amended Safety Assessment of Hydroquinone as Used in Cosmetics

来源: 美国CIR 安全性评估

Reviewed by CIR: Final Report on the Safety Assessment of Hydroquinone and Pyrocatechol (Pyrocatechol has been Amended. IJT 16(S1) 11-58 1997.) (Hydroquinone has an Addendum. JACT 13(3) 167-230 1994.)

来源: 美国CIR 安全性评估

Reviewed by CIR: Final Amended Safety Assessment of Hydroquinone as Used in Cosmetics

来源: 美国CIR 安全性评估

Reviewed by CIR: Addendum to the Final Report on the Safety Assessment of Hydroquinone

来源: 美国CIR 安全性评估

详细资料——标示名称、识别编号、物性、试验记录、文献

官方标示名称和定义

日本化妆品工业联合会标示名称 ハイドロキノン: 本品は、次の化学式で表される芳香族化合物である。

来源: 日本化妆品工业联合会标示名称

别名和识别信息

HYDROQUINONEINCI하이드로퀴논韩国标示名称(食药处标准名)1,4-Benzenediol同义名ハイドロキノン日本标示名称
CAS No.化学物质登记号
123-31-9
EC No.欧盟化学品目录编号
204-617-8
DTXSID美国EPA化学品编号
DTXSID7020716
DTXCID美国EPA化合物编号
DTXCID70716
IUPAC
Benzene-1,4-diol
分子式
C6H6O2
分子量
110.112 g/mol

实测物性

性状
Hydroquinone appears as light colored crystals or solutions. May irritate the skin, eyes and mucous membranes. Mildly toxic by ingestion or skin absorption. · Large Crystals, Other Solid, Dry Powder, Liquid
气味
Odorless · 无臭
沸点
545 to 549 °F at 760 mmHg (EPA, 1998) · 285-287
熔点
338 to 340 °F (EPA, 1998) · 170-171
溶解性
10 to 50 mg/mL at 68 °F (NTP, 1992) · 6.72g/L at 20 deg C
密度
1.332 at 59 °F (EPA, 1998) - Denser than water, will sink
pH
4
熔点/凝固点
172.3 ℃
初沸点和沸程
287 ℃
闪点
165 ℃
蒸气压
0.0000253 hPa(25℃)
溶解度
72 g/ℓ(mg/L, 25℃)
比重
1.33
正辛醇/水分配系数(Kow)
0.59
自燃温度
515 ℃(at 1013 hPa)
分子量
110.1114

这是对物质本身测得的数值。韩国安全保健公团(KOSHA)的资料仅供编写和审核安全数据表参考,并非原料商品的规格。

来源: PubChem · 韩国安全保健公团 安全数据表

产品实际使用的用途

这是向美国 EPA 申报含该成分的 25 款产品的用途。其中包括化妆品以外的产品,排在前几行的即为该成分的主要用途。

  • Monomers5
  • Fragrance3
  • Dye3
  • Antioxidant2
  • Photosensitive agent2
  • Intermediate2
  • Processing aids not otherwise specified2
  • Stabilizing agent1
其余用途 5 项
  • Reducing agent1
  • Bleaching agent1
  • Catalyst1
  • Chemical reaction regulator1
  • Flavouring and nutrient1

来源: 美国EPA CompTox

刺激与致敏试验记录

记录有皮肤试验 10 项、眼部试验 5 项。

归类为中等1 项

试验结论基本一致(100%)。 这是对原料本身的试验记录,与成品中所含浓度下的刺激性不同。

查看全部 15 项试验
  • Skin Sens. 1
    Skin Sensitization · Screening
  • Skin sensitization - Category 1
    Skin Sensitization · Screening
  • High Frequency of Sensitization
    skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation)
  • High Frequency of Sensitization
    skin sensitisation: in vivo (LLNA) · Screening · equivalent or similar to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
  • Not classified
    Skin Irritation · Screening
  • Category 1
    Skin Sensitization · Screening
  • Skin Sens. 1
    Skin Sensitization · Authoritative
  • Category 6.5B (Category 1)
    Skin Sensitization · Read Across
  • Category 6.3A (Category 2)
    Skin Irritation · Read Across
  • Sh
    Skin Sensitization · Authoritative
  • Serious eye damage/eye irritation - Category 2
    Eye Irritation · Screening
  • Eye Dam. 1
    Eye Irritation · Authoritative
  • Eye Dam. 1
    Eye Irritation · Screening
  • Category 8.3A (Category 1)
    Eye Irritation · Read Across
  • Category 1
    Eye Irritation · Screening

来源: 美国EPA CompTox

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