Ingredient Dictionary

HYDROXY TETRAMETHYLPIPERIDINE OXIDE

4-hydroxy-TEMPO is a member of the class of aminoxyls that is TEMPO carrying a hydroxy substituent at position 4.

Definition

4-hydroxy-TEMPO is a member of the class of aminoxyls that is TEMPO carrying a hydroxy substituent at position 4. It is a radical scavenger which exhibits anti-inflammatory and analgesic properties. It has a role as a catalyst, an antineoplastic agent, a radical scavenger, a hepatoprotective agent, a neuroprotective agent, an anti-inflammatory agent, an apoptosis inducer and a nephroprotective agent. It is a member of aminoxyls and a hydroxypiperidine. It is functionally related to a TEMPO.

Source: PubChem

US FDA substance register · UNII U78ZX2F65X · registered name TEMPOL · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Hydroxy Tetramethylpiperidine Oxide is the organic compound that conforms to the formula:

Cosmetic roles

Slows spoilage by oxygenANTIOXIDANT

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Reviewed by CIR: Safety Assessment of Hydroxy Tetramethylpiperidine Oxide and Tris(Tetramethylhydroxypiperidinol)) Citrate as Used in Cosmetics

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name ヒドロキシテトラメチルピぺリジンオキシド: 本品は、次の化学式で表される有機化合物である。

Source: JCIA labelling names (Japan)

Names & identifiers

HYDROXY TETRAMETHYLPIPERIDINE OXIDEINCI1-Piperidinyloxy, 4-hydroxy-2,2,6,6-tetramethyl-SynonymヒドロキシテトラメチルピぺリジンオキシドJapanese labelling name

CAS No.chemical registry number: 2226-96-2
EC No.EU chemical inventory number: 218-760-9
DTXSIDUS EPA chemical ID: DTXSID4041280
DTXCIDUS EPA compound ID: DTXCID2021280

IUPAC: (4-Hydroxy-2,2,6,6-tetramethylpiperidin-1-yl)oxidanyl
Molecular formula: C9H18NO2
Molecular weight: 172.248 g/mol

Measured properties

Appearance: CBI, Dry Powder, Other Solid · Solid, [Merck Index]
Melting point: 71.5 °C
Colour: Orange crystals
Melting/freezing point: 67~70 ℃
Initial boiling point and range: 269 ℃
Flash point: 146 ℃
Vapour pressure: 0.075 ㎜Hg (20℃)
Water solubility: 1670000 ㎎/ℓ (20℃)
Relative density: 1.187
n-Octanol/water partition coefficient (Kow): 0.54
Auto-ignition temperature: 260 ℃
Viscosity: 0.43 cP (50℃)
Molecular weight: 172.28

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 18 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Processing aids not otherwise specified3
Antioxidant3
Intermediate3
Catalyst3
UV stabilizer2
Chemical reaction regulator1
Corrosion inhibitor1
Absorbent1

1 other uses

Solvent1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

1 skin studies and 1 eye studies are on record.

Classed as low1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 2 studies

Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) July 17, 1992
Category 6.4A (Category 2A)
Eye Irritation · Read Across