What is this ingredient?

미국 FDA 물질 등록 · UNII G1L3HT4CMH · 등록명 HYDROXYACETOPHENONE · 단일 화학물질

Are there usage precautions?

피부 진정 효과 (추천 피부타입: 모든 피부 타입)

All ingredients

Ingredient Dictionary

HYDROXYACETOPHENONE

4'-hydroxyacetophenone is a monohydroxyacetophenone carrying a hydroxy substituent at position 4'.

How much products actually contain

No product states its amount yet.

Of the products containing it, 1,713 list it before the 1% line and 735 after it (usually 1% or less).

Products using this ingredient

12 of 2,431 confirmed · likeliest to carry enough first · See all 2,431

Definition

US FDA substance register · UNII G1L3HT4CMH · registered name HYDROXYACETOPHENONE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

4'-hydroxyacetophenone is a monohydroxyacetophenone carrying a hydroxy substituent at position 4'. It has a role as a mouse metabolite, a plant metabolite and a fungal metabolite.

Source: PubChem

Hydroxyacetophenone is the organic compound

Cosmetic roles

Slows spoilage by oxygenANTIOXIDANT

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Reviewed by CIR: Final Report: Safety Assessment of Hydroxyacetophenone as Used in Cosmetics

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name ヒドロキシアセトフェノン: 本品は、次の化学式で表される有機化合物である。

Source: JCIA labelling names (Japan)

Names & identifiers

HYDROXYACETOPHENONEINCI하이드록시아세토페논Korean label name (MFDS standard)Ethanone, 1-(4-hydroxyphenyl)-SynonymヒドロキシアセトフェノンJapanese labelling name

CAS No.chemical registry number: 99-93-4
EC No.EU chemical inventory number: 202-802-8
DTXSIDUS EPA chemical ID: DTXSID0029133
DTXCIDUS EPA compound ID: DTXCID209133

IUPAC: 1-(4-Hydroxyphenyl)ethan-1-one
Molecular formula: C8H8O2
Molecular weight: 136.15 g/mol

Measured properties

Appearance: Other Solid, Liquid · White or off-white powder, [Alfa Aesar MSDS]
Solubility: Practically insoluble or insoluble in water · Soluble (in ethanol)
Melting/freezing point: 110 ℃
Initial boiling point and range: 132.71 ℃(1hPa)
Flash point: 121.2 ℃
Flammability (solid, gas): not flammable
Vapour pressure: 0.00319 ㎩ (25 °C)
Water solubility: 10000 ㎎/ℓ
Vapour density: 1.27 (20℃)
Relative density: 1.14
n-Octanol/water partition coefficient (Kow): 1.1934
Molecular weight: 136.1479

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 8 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Antioxidant2
Flavouring and nutrient2
Fragrance2
Preservative1
Intermediate1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

3 skin studies and 0 eye studies are on record.

Classed as low2

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 3 studies

Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to EPA OTS 798.4100 (Skin Sensitisation)
SkinSens1
Skin Sensitization · QSAR Predicted
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · EPA OTS 798.4470 (Acute Dermal Irritation) according to