Hydroxyapatite is a mineral obtained from pearl oyster shells, salmon bones, phosphate rock, or derived synthetically.
How much products actually contain
No product states its amount yet.
Of the products containing it, 17 list it before the 1% line and 8 after it (usually 1% or less).
Products using this ingredient
12 of 25 confirmed · likeliest to carry enough first · See all 25
Dr. SquatchDr. Squatch Citrus Mint Whitening Toothpaste
Dr. SquatchDr. Squatch Soothing Spearmint - Night
Dr. SquatchDr. Squatch Spearmint Whitening Toothpaste
BiteBite Mouthwash
LAKAPerfect Twin Lip (Color 4.7g + Gloss
TatchaTatcha The Clarifying Clay Mask
MorpheMorphe Cloudlight Soft Glow Diffused Blush
BIOHEAL BOHProbioderm 3D Lifting Biotoxil PLGA Serum 30ml
THE SAEMTHE SAEM Eco Soul Bounce Powder 01 Ivory
OHUI3HR Blurring Sun Powder
COSMECHEFLip Balm
amikaamika big embrace | smoothing whipped body butter
Definition
US FDA substance register · UNII 91D9GV0Z28 · registered name TRIBASIC CALCIUM PHOSPHATE · single chemical substance
Hydroxyapatite is a mineral obtained from pearl oyster shells, salmon bones, phosphate rock, or derived synthetically. It conforms generally to the formula
Cosmetic roles
Safety & regulatory references
- Allowed colourant
- United States
Source: US FDA prohibited and restricted ingredients
European Union
- Product Type, body parts : (a) Toothpaste (b) Mouthwash
- Maximum concentration in ready for use preparation : (a) 10 % (b) 0,465 %
- Other : For (a) and (b): Not to be used in applications that may lead to exposure of the end-user’s lungs by inhalation. Only nanomaterials having the following characteristics are allowed: — [composed of] rod-shaped particles of which at least 95,8 % (in particle number) have an aspect ratio less than 3, and the remaining 4,2 % have an aspect ratio not exceeding 4,9; — the particles are not coated or surface modified
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
EU Cosmetics Regulation, Annex III (restricted substances), entry 372 · maximum concentration (a) 10 % (b) 0,465 % · applies to (a) Toothpaste (b) Mouthwash
Other restriction: ban substances that deplete the ozone layer · SCCS opinion: OPINION ON Hydroxyapatite (nano); SCIENTIFIC ADVICE on the safety of nanomaterials in cosmetics
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ヒドロキシアパタイト: 本品は、リン酸塩鉱石から得られる無機物であり、次の化学式で表される。
Source: JCIA labelling names (Japan)
JCIA labelling name ヒドロキシアパタイトＣａ: 本品は、次の化学式で表される合成鉱物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 12167-74-7
- CAS No.chemical registry number
- 1306-06-5
- EC No.EU chemical inventory number
- 215-145-7
- DTXSIDUS EPA chemical ID
- DTXSID10872538
Measured properties
- Appearance
- Dry Powder · Solid, [Merck Index] White suspension, [MSDSonline]
- Solubility
- Practically insol in water, even when freshly prepared
- Density
- Density: 3.1 to 3.2 /Apatite/ · 3.14 @ 20°C
- Colour
- white
- Odour
- odourless
- Melting/freezing point
- &, gt, 500 ℃
- Vapour density
- 3.16 g/㎤
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 9 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Processing aids not otherwise specified2
- Softener and conditioner2
- Filler2
- Abrasive1
- Lubricating agent1
- Flame retardant1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
1 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 2 studies
- Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - Studies Indicate No Significant Irritation
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 492 (Reconstructed Human Cornea-like Epithelium (RhCE) Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage) EpiOcular(TM) kit according to
Source: US EPA CompTox dashboard
Related literature
- Volumization and Global Biostimulation Using Calcium Hydroxyapatite Filler: A Dual Approach for Hand Rejuvenation · 2023
- Radiographic Manifestation of Cosmetic Hand Rejuvenation With Calcium Hydroxyapatite · 2025
- Minimally Invasive Facial Lifting Using the Versatility of Calcium Hydroxyapatite (STIIM) · 2025
- Comparative histomorphological evaluation of the effectiveness of combined injection of stabilized hyaluronic acid and calcium hydroxyapatite-based agents · 2023
- Management of infected hydroxyapatite cranioplasty: Is salvage feasible? · 2022
Linked databases 25
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2 3
- EU Cosmetics Regulation
- EU restricted substances (Annex III)
- EU SCCS safety opinions 2 3
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3 4
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard
- US EPA DSSTox chemical database
- US FDA prohibited and restricted ingredients
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese