Ingredient Dictionary

HYDROXYCORTISONE SUCCINATE

Hydrocortisone succinate is a derivative of succinic acid in which one of the carboxy groups is esterified by the C-21 hydroxy group of cortisol (hydrocortisone).

Definition

Hydrocortisone succinate is a derivative of succinic acid in which one of the carboxy groups is esterified by the C-21 hydroxy group of cortisol (hydrocortisone). It is a hemisuccinate, a tertiary alpha-hydroxy ketone and a dicarboxylic acid monoester. It is functionally related to a cortisol.

Source: PubChem

US FDA substance register · UNII IHV1VP592V · registered name Hydrocortisone hemisuccinate anhydrous · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Keeps skin in good condition (CosIng catch-all)SKIN CONDITIONING

Safety & regulatory references

Banned: Argentina · ASEAN · Brazil · Canada · China · European Union · South Korea

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Restriction II/300

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Names & identifiers

HYDROXYCORTISONE SUCCINATEINCI하이드록시코르티손석시네이트Korean label name (MFDS standard)

CAS No.chemical registry number: 2203-97-6
EC No.EU chemical inventory number: 218-612-3
DTXSIDUS EPA chemical ID: DTXSID40872905
DTXCIDUS EPA compound ID: DTXCID10820453

IUPAC: 4-[(11beta,17-Dihydroxy-3,20-dioxopregn-4-en-21-yl)oxy]-4-oxobutanoic acid
Molecular formula: C25H34O8
Molecular weight: 462.539 g/mol

Measured properties

Water solubility: 1233 ㎎/ℓ
n-Octanol/water partition coefficient (Kow): 0.47
Molecular weight: 462.59

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Softener and conditioner1

Source: US EPA CompTox dashboard