Ingredient Dictionary

HYDROXYETHOXY AMINOPYRAZOLOPYRIDINE HCL

Definition

Hydroxyethoxy Aminopyrazolopyridine HCl is the organic compound

Cosmetic roles

Dyes hairHAIR DYEING

Safety & regulatory references

Restricted: Taiwan · United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic regulations · UK cosmetics regulations (OPSS)

ASEAN

Field of application and/or use : Hair dye substance in oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
Other limitations and requirements : After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2.0% The direction for use “wear suitable gloves” must be included in label or leaflet text.
Conditions of use and warning which must be printed on the labels : To be printed on the label: “Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: - you have a rash on your face or sensitive, irritated and damaged scalp, - you have ever experienced any reaction after colouring your hair, - you have experienced a reaction to a temporary ‘black henna’ tattoo in the past. Do not use to dye eyelashes or eyebrows.”

European Union

Product Type, body parts : Hair dye substance in oxidative hair dye products
Other : after mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2,0 %
Wording of conditions of use and warnings : The mixing ratio. ‘ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary “black henna” tattoo in the past.

Source: MFDS (Korea) cosmetic regulatory information

EU Cosmetics Regulation, Annex III (restricted substances), entry 302 · applies to Hair dye substance in oxidative hair dye products

Source: EU restricted substances (Annex III)

Restriction III/302 · SCCS opinion: Opinion on Hydroxyethoxy aminopyrazolopyridine HCl

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Names & identifiers

HYDROXYETHOXY AMINOPYRAZOLOPYRIDINE HCLINCI하이드록시에틸아미노피라졸피리딘에이치씨엘Korean label name (MFDS standard)

CAS No.chemical registry number: 1079221-49-0
EC No.EU chemical inventory number: 695-745-7
DTXSIDUS EPA chemical ID: DTXSID801024736
DTXCIDUS EPA compound ID: DTXCID701508919

IUPAC: 2-[(3-Aminopyrazolo[1,5-a]pyridin-2-yl)oxy]ethan-1-ol--hydrogen chloride (1/1)
Molecular formula: C9H12ClN3O2
Molecular weight: 229.66 g/mol

What products actually use it for

What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Dye1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

2 skin studies and 1 eye studies are on record.

Classed as highly irritating1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 3 studies

Ambiguous
skin corrosion: in vitro / ex vivo · Screening · OECD Guideline 439 (In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method) equivalent or similar to
High Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) according to EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay)
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to