HYDROXYETHOXYPHENYL BUTANONE

US FDA substance register · UNII TH7XI54W45 · registered name 4-(3-ETHOXY-4-HYDROXYPHENYL)-2-BUTANONE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Ethylzingerone is a methyl ketone that is 4-phenylbutan-2-one in which the phenyl ring is substituted at positions 3 and 4 by ethoxy and hydroxy groups, respectively. It is a preservative with antimicrobial activity and a good safety profile that has been approved for use in cosmetics. It is structurally similar to zingerone, a phytochemical found in the root of the ginger plant Zingiber officinale. It has a role as an antimicrobial cosmetic preservative, an antibacterial agent and an antifungal agent. It is a member of phenols, an aromatic ether and a methyl ketone.

Source: PubChem

Hydroxyethoxyphenyl Butanone is the organic compound that conforms to the formula:

Allowed preservative

United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · UK cosmetics regulations (OPSS)

Argentina · Brazil

• Maximum concentration permitted at final product : 0.7%

ASEAN

• Maximum authorised concentration in the finished cosmetic product : 0.7 %

European Union

• Product Type, body parts : Allowed for use as a preservative in rinse off, oral care and leave-on cosmetic products at a maximum concentration of 0,7 % in ready for use preparation
• Maximum concentration in ready for use preparation : 0.7%

EU Cosmetics Regulation, Annex V (allowed preservatives), entry 60 · maximum concentration 0.7 % · applies to Allowed for use as a preservative in rinse off, oral care and leave-on cosmetic products at a maximum concentration of 0,7 % in ready for use preparation.

Source: EU allowed preservatives (Annex V)

SCCS opinion: OPINION ON Ethylzingerone - ‘Hydroxyethoxyphenyl Butanone’ (HEPB) - Cosmetics Europe No P98 – CAS No 569646-79-3 Submission II (eye irritation); OPINION ON Ethylzingerone –‘Hydroxyethoxyphenyl Butanone’ (HEPB)

Source: EU CosIng ingredient list