Ingredient Dictionary

HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID

2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid is a HEPES that is ethanesulfonic acid in which one of the methyl hydrogens is replaced by a 4-(2-hydroxyethyl)piperazin-1-yl group.

How much products actually contain

No product states its amount yet.

Of the products containing it, 6 list it before the 1% line and 5 after it (usually 1% or less).

Products using this ingredient

11 of 11 confirmed · likeliest to carry enough first

Definition

2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid is a HEPES that is ethanesulfonic acid in which one of the methyl hydrogens is replaced by a 4-(2-hydroxyethyl)piperazin-1-yl group. A Good's buffer substance, pKa = 7.55 at 20 C. It is an organosulfonic acid and a HEPES. It is a conjugate acid of a 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonate. It is a tautomer of a 2-[4-(2-hydroxyethyl)piperazin-4-ium-1-yl]ethanesulfonate.

Source: PubChem

US FDA substance register · UNII RWW266YE9I · registered name HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Keeps pH steadyBUFFERING

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name ヒドロキシエチルピペラジンエタンスルホン酸: 本品は、次の化学式で表される複素環式化合物である。

Source: JCIA labelling names (Japan)

Names & identifiers

HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACIDINCI하이드록시에틸피페라진에탄설포닉애씨드Korean label name (MFDS standard)1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-Synonymヒドロキシエチルピペラジンエタンスルホン酸Japanese labelling name

CAS No.chemical registry number: 7365-45-9
EC No.EU chemical inventory number: 230-907-9
DTXSIDUS EPA chemical ID: DTXSID5040382
DTXCIDUS EPA compound ID: DTXCID3020382

IUPAC: 2-[4-(2-Hydroxyethyl)piperazin-1-yl]ethane-1-sulfonic acid
Molecular formula: C8H18N2O4S
Molecular weight: 238.3 g/mol

Measured properties

Appearance: Dry Powder, Liquid · Solid, [Merck Index] White powder, [Alfa Aesar MSDS]
Colour: white
Melting/freezing point: 234 ℃
n-Octanol/water partition coefficient (Kow): -4.070
Molecular weight: 238.31

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 3 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

pH regulating agent3

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

4 skin studies and 1 eye studies are on record.

Classed as low2

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 5 studies

Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation)
SkinSens1
Skin Sensitization · QSAR Predicted
SkinIrr2
Skin Irritation · QSAR Predicted
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to