12-hydroxyoctadecanoic acid is a hydroxy fatty acid that is stearic acid bearing a hydroxy substituent at position 12.
How much products actually contain
No product states its amount yet.
Of the products containing it, 12 list it before the 1% line and 19 after it (usually 1% or less).
Products using this ingredient
12 of 29 confirmed · likeliest to carry enough first · See all 29
e.l.f.e.l.f. Suntouchable Invisi-Stick SPF 50
Nails.INCNails.INC Sleep, Love, Repeat Nourishing Lip Balm
Nails.INCNails.INC Watch Me Go Nourishing Lip Balm
Scotch PorterScotch Porter Beard & Mustache Styling Wax
Makeup By MarioMakeup By Mario Master Secret Glow®
Nails.INCNails.INC Hint of Chill Nourishing Lip Balm
KeyboPlump Lip Plus Lip Plumper (19 Colors)
ILIAILIA Lip Wrap Overnight Mask
wet n wildwet n wild Color-Changing Blush | Velvet Void
SKIN1004SKIN1004 Probio-Cica Intensive Ampoule
HourglassHourglass Unlocked Satin Crème Lipstick
HourglassHourglass Unlocked Satin Crème Lipstick Red 0
Definition
12-hydroxyoctadecanoic acid is a hydroxy fatty acid that is stearic acid bearing a hydroxy substituent at position 12. It has a role as a plant metabolite and a bacterial xenobiotic metabolite. It is a hydroxyoctadecanoic acid and a secondary alcohol. It is a conjugate acid of a 12-hydroxyoctadecanoate.
Source: PubChem
US FDA substance register · UNII 933ANU3H2S · registered name 12-HYDROXYSTEARIC ACID · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
Reviewed by CIR: Amended Final Report on the Safety Assessment of Hydroxystearic Acid
Reviewed by CIR: Final Report: Safety Assessment of Fatty Acids and Fatty Acid Salts as Used in Cosmetics
Reviewed by CIR: Re-evaluation: Safety Assessment of Hydroxystearic Acid as Used in Cosmetics
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ヒドロキシステアリン酸: 本品は、次の化学式で表される脂肪酸である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 106-14-9
- CAS No.chemical registry number
- 1330-70-7
- EC No.EU chemical inventory number
- 203-366-1
- EC No.EU chemical inventory number
- 215-545-1
- DTXSIDUS EPA chemical ID
- DTXSID8026725
- DTXCIDUS EPA compound ID
- DTXCID606725
- IUPAC
- 12-Hydroxyoctadecanoic acid
- Molecular formula
- C18H36O3
- Molecular weight
- 300.483 g/mol
Measured properties
- Appearance
- solid
- Melting/freezing point
- 82 ℃
- Initial boiling point and range
- 436 ℃
- Flash point
- 185 ℃
- Vapour pressure
- (2E-9 (25 C))
- Water solubility
- 0.04243 ㎎/ℓ
- Relative density
- 0.9-1.0
- n-Octanol/water partition coefficient (Kow)
- 6.03
- Decomposition temperature
- 204 ℃
- Molecular weight
- 300.48
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 24 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Surfactant (surface active agent)6
- Lubricating agent5
- Cleaning agent2
- Emulsifier2
- Plasticizer2
- Processing aids not otherwise specified1
- Monomers1
- Thickening agent1
4 other uses
- Heat stabilizer1
- Intermediate1
- Corrosion inhibitor1
- Antioxidant1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
4 skin studies and 0 eye studies are on record.
The studies disagree (the most common conclusion covers 50%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 4 studies
- SkinIrr2
Skin Irritation · QSAR Predicted - Ambiguous
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) according to EU Method B.6 (Skin Sensitisation) - High Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) according to EU Method B.6 (Skin Sensitisation)
Source: US EPA CompTox dashboard
Related literature
- 12-hydroxystearic acid-mediated in-situ surfactant generation: A novel approach for organohydrogel emulsions. · 2024
- Formulation and Characterization of Curcumin 12-Hydroxystearic Acid in Triacetin Organogel for Topical Administration · 2024
- Bio‐derived hydroxystearic acid ameliorates skin age spots and conspicuous pores · 2019
- Niacinamide and 12‐hydroxystearic acid prevented benzo(a)pyrene and squalene peroxides induced hyperpigmentation in skin equivalent · 2018
- Allergic contact dermatitis caused by bis‐diglycerylpolyacyladipate‐2 (Softisan® 649) owing to its 12‐hydroxystearic acid content · 2011
Linked databases 21
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3 4
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Chinese