5-hydroxytryptophan is a tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
Definition
5-hydroxytryptophan is a tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5. It has a role as a neurotransmitter and a human metabolite.
Source: PubChem
US FDA substance register · UNII 9181P3OI6N · registered name 5-HYDROXYTRYPTOPHAN, DL- · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ヒドロキシトリプトファン: 本品は、次の化学式で表される有機化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 56-69-9
- EC No.EU chemical inventory number
- 200-284-8
- DTXSIDUS EPA chemical ID
- DTXSID50859863
- DTXCIDUS EPA compound ID
- DTXCID90208816
- IUPAC
- 5-Hydroxytryptophan
- Molecular formula
- C11H12N2O3
- Molecular weight
- 220.228 g/mol
Measured properties
- Appearance
- Minute rods or needles from ethanol · solid
- Melting point
- 298-300 °C (decomposes) · MP: 273 °C (decomposes), specific optical rotation: +16.0 deg at 22 °C (c=1 in 4M HCl), -32 deg at 22 °C (c=1 in H2O) /(S)-5-Hydroxytryptophan/
- Solubility
- Solubilities: 2.5 g/100 mL in 50% boiling alcohol, 5.5 g/100 mL in water at 100 °C · In water, 1X10+4 mg/L at 5 °C
- Stability
- AQ SOLN ARE STABLE @ LOW PH /DL-FORM/
- Melting/freezing point
- 298 ℃
- Molecular weight
- 220.22
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner1
Source: US EPA CompTox dashboard
Related literature
- Chemical modification of 5-hydroxytryptophan photoinduced by endogenous sensitizers present in skin · 2024
- 5‐hydroxytryptophan attenuates imiquimod‐induced psoriasiform dermatitis probably through inhibition of IL‐17A production and keratinocyte activation · 2018
- Drug-induced chimerism and prevention of graft-versus-host disease in lethally irradiated mice transplanted with rat bone marrow. · 1978
- The effect of parachlorophenylalanine on the behaviour of cats · 1970
- 5-Methoxy- and 5-hydroxyindoles in the skin of Bufo alvarius. · 1967
Linked databases 15
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata