Ibuprofen is a monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group.
定义
美国FDA 物质登记 · UNII WK2XYI10QM · 登记名称 Ibuprofen · 单一化学物质
Ibuprofen is a monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group. It has a role as a geroprotector, a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic, a xenobiotic, a radical scavenger, a cyclooxygenase 2 inhibitor, a cyclooxygenase 1 inhibitor, an environmental contaminant and a drug allergen. It is functionally related to a propionic acid. It is a conjugate acid of an ibuprofen(1-).
来源: PubChem
化妆品中的作用
安全与法规参考
未列入韩国有毒物质 GHS 分类 · 现有化学物质
Other restriction: ban substances that deplete the ozone layer
来源: 欧盟 CosIng 成分清单
详细资料——标示名称、识别编号、物性、试验记录、文献
别名和识别信息
- CAS No.化学物质登记号
- 15687-27-1
- EC No.欧盟化学品目录编号
- 239-784-6
- DTXSID美国EPA化学品编号
- DTXSID5020732
- DTXCID美国EPA化合物编号
- DTXCID90732
- IUPAC
- 2-[4-(2-Methylpropyl)phenyl]propanoic acid
- 分子式
- C13H18O2
- 分子量
- 206.285 g/mol
实测物性
- 性状
- Other Solid · Solid
- 气味
- Characteristic odor
- 沸点
- 157 ºC
- 熔点
- 75-77.5 ºC · 75-77 °C
- 溶解性
- 21 mg/L (at 25 °C) · Readily sol in most org solvents
- 稳定性
- STABLE
- 解离常数
- 4.45 · 5.3
这是对物质本身测得的数值，并非原料商品的规格。
来源: PubChem
产品实际使用的用途
这是向美国 EPA 申报含该成分的 6 款产品的用途。其中包括化妆品以外的产品，排在前几行的即为该成分的主要用途。
- Pharmaceutical (EPA)5
- Softener and conditioner1
来源: 美国EPA CompTox
刺激与致敏试验记录
记录有皮肤试验 4 项、眼部试验 1 项。
试验结论基本一致（100%）。 这是对原料本身的试验记录，与成品中所含浓度下的刺激性不同。
查看全部 5 项试验
- Classification not possible
Skin Sensitization · Screening - Classification not possible
Skin Irritation · Screening - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) (1981) - SkinIrr2
Skin Irritation · QSAR Predicted - Classification not possible
Eye Irritation · Screening
来源: 美国EPA CompTox
相关文献
- Comparative evaluation of ibuprofen and ibuprofen sodium nano micelles loaded dissolving microneedles in healthy human volunteers. · 2025
- Evaluation of the Structural Modification of Ibuprofen on the Penetration Release of Ibuprofen from a Drug-in-Adhesive Matrix Type Transdermal Patch · 2022
- Comparison of diclofenac gel, ibuprofen gel, and ibuprofen gel with levomenthol for the topical treatment of pain associated with musculoskeletal injuries · 2019
- Characterization of Patients with Ibuprofen Hypersensitivity · 2018
- Pelepasan Ibuprofen dari Gel Karbomer 940 Kokristal Ibuprofen-Nikotinamida · 2015