Icariside II is a glycosyloxyflavone that is 3,5,7-trihydroxy-4'-methoxy-8-prenylflavone in which the hydroxy group at position 3 has been converted into its alpha-L-rhamnopyranoside.
Definition
Icariside II is a glycosyloxyflavone that is 3,5,7-trihydroxy-4'-methoxy-8-prenylflavone in which the hydroxy group at position 3 has been converted into its alpha-L-rhamnopyranoside. It has a role as an antineoplastic agent, an anti-inflammatory agent, an apoptosis inducer and a plant metabolite. It is functionally related to an alpha-L-rhamnopyranose.
Source: PubChem
Cosmetic roles
Safety & regulatory references
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name イカリシドⅡ: 本品は、次の化学式で表される有機化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 113558-15-9
- DTXSIDUS EPA chemical ID
- DTXSID40150457
- DTXCIDUS EPA compound ID
- DTXCID4072948
- IUPAC
- 5,7-Dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-1-benzopyran-3-yl 6-deoxy-alpha-L-mannopyranoside
- Molecular formula
- C27H30O10
- Molecular weight
- 514.527 g/mol
What products actually use it for
What the 5 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner2
- Bleaching agent1
- Humectant1
- Antioxidant1
Source: US EPA CompTox dashboard
Related literature
- Xianling Lianxia formula enhances the inhibitory effects of trastuzumab on HER2-positive breast cancer · 2023
- Epimedium brevicornum Maxim. Extract exhibits pigmentation by melanin biosynthesis and melanosome biogenesis/transfer · 2022
- Icariside II overcomes BRAF inhibitor resistance in melanoma by inducing ROS production and inhibiting MITF. · 2020
- Blockade of epidermal growth factor receptor/mammalian target of rapamycin pathway by Icariside II results in reduced cell proliferation of osteosarcoma cells. · 2014
- Icariside II induces apoptosis via inhibition of the EGFR pathways in A431 human epidermoid carcinoma cells. · 2013