Imidurea is a member of ureas.
- Korean limit
- 0.60%
How much products actually contain
No product states its amount yet.
Of the products containing it, 2 list it before the 1% line and 5 after it (usually 1% or less).
Products using this ingredient
7 of 7 confirmed · likeliest to carry enough first
Definition
US FDA substance register · UNII M629807ATL · registered name IMIDUREA · single chemical substance
Imidurea is a member of ureas. It has a role as an antimicrobial agent.
Source: PubChem
Imidazolidinyl Urea is the heterocyclic substituted urea that conforms to the formula:
Cosmetic roles
Safety & regulatory references
- Allowed preservative
- United Kingdom
Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)
Argentina · Brazil
- Maximum concentration permitted at final product : 0.6%
ASEAN
- Maximum authorised concentration in the finished cosmetic product : 0.6%
Taiwan
- Maximum concentration : 0.6%
- 0.6%
Japan
- Maximum amount per 100 g (Cosmetics not used for mucosa and to be washed away) : 0.30 g
China
- Maximum concentration : 0.6%
South Korea
- Maximum concentration : 0.60%
European Union
- Maximum concentration in ready for use preparation : 0.6%
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
EU Cosmetics Regulation, Annex V (allowed preservatives), entry 27 · maximum concentration 0.6%
Restriction V/27 · SCCS opinion: SCIENTIFIC ADVICE ON the threshold for the warning ‘contains formaldehyde’ in Annex V, preamble point 2 for formaldehyde-releasing substances
Source: EU CosIng ingredient list
Reviewed by CIR: Imidazolidinyl Urea
Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessment - 2001/2002
Reviewed by CIR: Final Report of the Safety Assessment for Imidazolidinyl Urea
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name イミダゾリジニルウレア: 本品は、次の化学式で表される複素環置換尿素である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 39236-46-9
- EC No.EU chemical inventory number
- 254-372-6
- DTXSIDUS EPA chemical ID
- DTXSID2040151
- DTXCIDUS EPA compound ID
- DTXCID0020151
- IUPAC
- N,N'-Methylenebis{N'-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]urea}
- Molecular formula
- C11H16N8O8
- Molecular weight
- 388.297 g/mol
Measured properties
- Appearance
- Exists as the monohydrate: White odorless solid, [Merck Index]
- n-Octanol/water partition coefficient (Kow)
- &, lt, 0.9
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 22 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Preservative21
- Processing aids not otherwise specified1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
4 skin studies and 3 eye studies are on record.
The study conclusions largely agree (67%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 7 studies
- SkinSens1
Skin Sensitization · QSAR Predicted - High Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · equivalent or similar to OECD Guideline 442A (Skin Sensitization: Local Lymph Node Assay: DA) - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: US Federal Register 26, 1961: section 191.11 according to - High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation) equivalent or similar to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - Category 6.4A (Category 2A)
Eye Irritation · Read Across - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: US Federal Register 29 (1964), section191.12 according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to
Source: US EPA CompTox dashboard
Related literature
- Non-sensitizing Alternatives to Diazolidinyl Urea and Imidazolidinyl Urea as Preservatives in Cosmetics · 2026
- Development and Validation of New HPLC Method for the Determination of Imidazolidinyl Urea in Topical Formulation · 2024
- Imidazolidinyl Urea · 2023
- Erythrocyte Toxicities of Imidazolidinyl Urea and Diazolidinyl Urea · 2013
- Characterization of the decomposition of compounds derived from imidazolidinyl urea in cosmetics and patch test materials · 2012
Linked databases 26
- ASEAN Cosmetic Directive
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU allowed preservatives (Annex V)
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3 4
- PubChem 2
- Taiwan FDA cosmetic ingredients
- Tlooto literature search 2 3 4 5
- UK cosmetics regulations (OPSS)
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3 4
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English