1H-indole is an indole and a polycyclic heteroarene.
Definition
1H-indole is an indole and a polycyclic heteroarene. It has a role as an Escherichia coli metabolite. It is a tautomer of a 3H-indole.
Source: PubChem
US FDA substance register · UNII 8724FJW4M5 · registered name INDOLE · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 120-72-9
- EC No.EU chemical inventory number
- 204-420-7
- DTXSIDUS EPA chemical ID
- DTXSID0020737
- DTXCIDUS EPA compound ID
- DTXCID40737
- IUPAC
- 1H-Indole
- Molecular formula
- C8H7N
- Molecular weight
- 117.151 g/mol
Measured properties
- Appearance
- Dry Powder, Liquid · White to yellowish solid with an unpleasant odor, Pleasant odor in dilute solutions, Turns red when exposed to light or air, [Hawley] White or yellow crystalline powder, [MSDSonline]
- Odour
- ALMOST FLORAL ODOR WHEN HIGHLY PURIFIED, OTHERWISE EXHIBITS CHARACTERISTIC ODOR OF FECES · Unpleasant odor in high concentration but pleasant in dilute solution.
- Boiling point
- 254 °C · 253 °C @ 762 mm Hg, 128-133 °C @ 28 mm Hg
- Melting point
- 52.5 °C · 52 °C
- Solubility
- 3560 mg/L (at 25 °C) · SOL IN HOT WATER, HOT ALC, ETHER, BENZENE
- Density
- 1.22 g/cu cm at 25 °C
- Stability
- NOT VERY STABLE ON EXPOSURE TO LIGHT (TURNS RED)
- Dissociation constant
- pKa (basic)= -2.4
- Melting/freezing point
- 52 ℃
- Initial boiling point and range
- 253 ℃
- Flash point
- 108 ℃
- Upper/lower flammability or explosive limits
- 8.1 / - %
- Vapour pressure
- 0.03 ㎜Hg (25 C)
- Relative density
- 1.2
- n-Octanol/water partition coefficient (Kow)
- 2.14
- Molecular weight
- 117.14
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 21 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Fragrance19
- Flavouring and nutrient2
Source: US EPA CompTox dashboard
Related literature
- Unlocking the cytotoxic potential of Apocynaceae monoterpene indole and bis-indole alkaloids: a review. · 2026
- Anti-Tumor Activity of Indole: A Review · 2024
- Multiple-species hormetic phenomena induced by indole: A case study on the toxicity of indole to bacteria, algae and human cells. · 2019
- Indole derivatives as multifunctional drugs: Synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity of indole hydrazones. · 2019
- Hydrogen Abstraction of Ketoprofen in the Excited Triplet State with Indole and Methylindoles. · 2019
Linked databases 16
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese