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Ingredients

Ingredient Dictionary

IODOPROPYNYL BUTYLCARBAMATE

Molecular structure

How much products actually contain

No product states its amount yet.

Of the products containing it, 4 list it before the 1% line and 52 after it (usually 1% or less).

Products using this ingredient

12 of 56 confirmed · likeliest to carry enough first · See all 56

Definition

Iodopropynyl Butylcarbamate is the organic compound that conforms to the formula:

US FDA substance register · UNII 603P14DHEB · registered name Iodocarb · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

3-iodoprop-2-yn-1-yl butylcarbamate is a carbamate ester that is carbamic acid in which the nitrogen has been substituted by a butyl group and in which the hydrogen of the carboxy group is replaced by a 1-iodoprop-2-yn-3-yl group. A fungicide, it is used as a preservative and sapstain control chemical in wood products and as a preservative in adhesives, paints, latex paper coating, plastic, water-based inks, metal working fluids, textiles, and numerous consumer products. It has a role as a xenobiotic, an environmental contaminant and an antifungal agrochemical. It is a carbamate ester, an organoiodine compound, an acetylenic compound and a carbamate fungicide.

Source: PubChem

Cosmetic roles

Stops microbes growing in the productPRESERVATIVE

Safety & regulatory references

Restricted
South Korea · Taiwan
Allowed preservative
Taiwan · United Kingdom

Source: MFDS (Korea) cosmetic regulatory information · ASEAN Cosmetic Directive · EU Cosmetics Regulation · Japan Standards for Cosmetics · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)

Argentina · Brazil

  • Maximum concentration permitted at final product : a) 0.02% in rinse-off products b) 0.01% in products not RINSING to n, except in deodorants / antiperspirants c) 0.0075%. Deodorants / Antiperspirants
  • Other limitations and requirements : No use in products for oral hygiene and lip. a) No use in products for children under 3 years, except in bath products, shower gel and shampoo. b) No use in lotions and body creams that are applied in large extensions body; No use in products for children under 3 years of age. c) No use in lotions and body creams that are applied in large body extensions. No use in products for children.
  • Use conditions and warnings that must appear on the label : a) For products use Adults: "Do not use in children" For products aimed at children: "Do not use in children under three years of age" (This warning does not apply to bath products, shower gel and shampoo). b) For products use Adult: "Do not use in children" For products aimed at children: "Do not use in children under three years of age" c) Do not use in children

ASEAN

  • Maximum authorised concentration in the finished cosmetic product : (a) rinse-off products: 0.02 % (b) leave-on products: 0.01 % except in deodorants & antiperspirants: 0.0075 %
  • Other limitations and requirements : Not to be used in oral hygiene and lip care products (a) Not to be used in preparations for children under three years of age, except in bath products/shower gels and shampoos. (b) Not to be used in body lotion and body cream (Concerns any products aimed to be applied on a large part of the body) Not to be used in preparations for children under three years of age.
  • Conditions of use and warning which must be printed on the labels : (a) Not to be used for children under three years of age (Solely for products, other than bath products/shower gels and shampoo, which might be used for children under three years of age.) (b) Not to be used for children under three years of age (Solely for products which might be used for children under three years of age)

Japan

  • Maximum amount per 100 g (Cosmetics not used for mucosa and to be washed away) : 0.02 g
  • Maximum amount per 100 g (Cosmetics not used for mucosa and not to be washed away) : 0.02 g
  • Maximum amount per 100 g (Cosmetics that may be used for mucosa) : 0.02 g

China

  • Maximum concentration : (a) 0.02%
  • (b) 0.01%
  • (c) 0.0075%

European Union

  • Product Type, body parts : a) Rinse-off products b) Leave-on products c) Deodorants/antiperspirants
  • Maximum concentration in ready for use preparation : a) 0.02% b) 0.01% c) 0.0075%
  • Other : Not to be used in oral and lip products a) Not to be used in products for children under 3 years of age, except in bath products / shower gels and shampoos b) Not to be used in body lotion and body cream (13) b) and c) Not to be used in products for children under 3 years of age
  • Wording of conditions of use and warnings : a) Not to be used for children under three years of age (11) b) and c) Not to be used for children under three years of age (12)

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex V (allowed preservatives), entry 56 · maximum concentration a) 0.02% b) 0.01% c) 0.0075% · applies to a) Rinse-off products b) Leave-on products c) Deodorants/antiperspirants

Source: EU allowed preservatives (Annex V)

Restriction V/56 · Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

Reviewed by CIR: 40th Anniversary Overview and Rereview Summaries From 2011 to 2015

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name ブチルカルバミン酸ヨウ化プロピニル: 本品は、次の化学式で表されるカルバミン酸エステル誘導体である。

Source: JCIA labelling names (Japan)

Names & identifiers

IODOPROPYNYL BUTYLCARBAMATEINCI아이오도프로피닐부틸카바메이트Korean label name (MFDS standard)Carbamic acid, butyl-, 3-iodo-2-propynyl esterSynonymブチルカルバミン酸ヨウ化プロピニルJapanese labelling name
CAS No.chemical registry number
55406-53-6
EC No.EU chemical inventory number
259-627-5
DTXSIDUS EPA chemical ID
DTXSID0028038
DTXCIDUS EPA compound ID
DTXCID908038
IUPAC
3-Iodoprop-2-yn-1-yl butylcarbamate
Molecular formula
C8H12INO2
Molecular weight
281.093 g/mol

Measured properties

Appearance
3-iodo-2-propynyl butylcarbamate is an off-white solid. · White solid with a pungent odor, [HSDB]
Odour
Sharp pungent odor
Melting point
66 °C
Solubility
In water, 156 mg/L at 20 °C
Density
1.575 g/mL · 1.575 @25 °C
Colour
grey
Odour threshold
156 ppm (156ppm at 20C)
Melting/freezing point
66 ℃
Vapour pressure
0.0000525 ㎜Hg
Water solubility
156 ㎎/ℓ (at 20℃)
Relative density
1.575
n-Octanol/water partition coefficient (Kow)
2.4
Molecular weight
281

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 87 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

  • Preservative42
  • Biocide37
  • Processing aids not otherwise specified8

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

9 skin studies and 4 eye studies are on record.

Classed as moderate1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 13 studies
  • Skin irritation - category 2
    Skin Irritation · Screening
  • Sh
    Skin Sensitization · Authoritative
  • Skin Sens. 1
    Skin Sensitization · Authoritative
  • Skin sensitisation - category 1
    Skin Sensitization · Screening
  • Category 6.3B (Category 3)
    Skin Irritation · Read Across
  • Category 6.5B (Category 1)
    Skin Sensitization · Read Across
  • High Frequency of Sensitization
    skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) 1992 according to EPA OPPTS 870.2600 (Skin Sensitisation) 1998 according to EU Method B.6 (Skin Sensitisation)
  • Studies Indicate No Significant Irritation
    skin irritation: in vivo · Screening · EPA OPP 81-5 (Acute Dermal Irritation) according to
  • Not likely to be sensitizing
    skin sensitisation: in vivo (non-LLNA) · Screening · according to EPA OPP 81-6 (Skin Sensitisation) 1987 according to OECD Guideline 406 (Skin Sensitisation) 1992
  • Eye damage - category 1
    Eye Irritation · Screening
  • Eye Dam. 1
    Eye Irritation · Authoritative
  • Corrosive or Irritation Persists for > 21 days
    eye irritation: in vivo · Screening · EPA OPP 81-4 (Acute Eye Irritation) according to
  • Category 6.4A (Category 2A)
    Eye Irritation · Read Across

Source: US EPA CompTox dashboard

Related literature

Linked databases 28