Isatin is an indoledione that is the 2,3-diketo derivative of indole.
Definition
Isatin is an indoledione that is the 2,3-diketo derivative of indole. It has a role as an EC 1.4.3.4 (monoamine oxidase) inhibitor and a plant metabolite.
Source: PubChem
US FDA substance register · UNII 82X95S7M06 · registered name ISATIN · single chemical substance
Cosmetic roles
Safety & regulatory references
- Restricted
- Taiwan · United Kingdom
Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · Taiwan FDA cosmetic regulations · UK cosmetics regulations (OPSS)
ASEAN
- Field of application and/or use : Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
- Maximum authorised concentration in the finished cosmetic product : 1.6%
- Other limitations and requirements : The direction for use “wear suitable gloves” must be included in label or leaflet text.
- Conditions of use and warning which must be printed on the labels : The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past Do not use to dye eyelashes or eyebrows
European Union
- Product Type, body parts : Hair dye substance in non-oxidative hair dye products
- Maximum concentration in ready for use preparation : 1.6%
- Wording of conditions of use and warnings : Hair colorants can cause severe allergic reactions.
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
EU Cosmetics Regulation, Annex III (restricted substances), entry 210 · maximum concentration 1.6% · applies to Hair dye substance in non-oxidative hair dye products
Restriction Annex III/210 · Other restriction: ban substances that deplete the ozone layer · SCCS opinion: Opinion on Isatin
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 91-56-5
- EC No.EU chemical inventory number
- 202-077-8
- DTXSIDUS EPA chemical ID
- DTXSID3038694
- DTXCIDUS EPA compound ID
- DTXCID1018694
- IUPAC
- 1H-Indole-2,3-dione
- Molecular formula
- C8H5NO2
- Molecular weight
- 147.133 g/mol
Measured properties
- Appearance
- Orange solid, [Merck Index] Orange odorless powder, [Alfa Aesar MSDS] · solid
- Melting point
- 203 dec °C · 203.00 °C. @ 760.00 mm Hg
- Flash point
- 220 ℃
- Flammability (solid, gas)
- flammable
- Vapour pressure
- 0.0000111 ㎜Hg (@ 25 ℃, est.)
- Water solubility
- 15300 ㎎/ℓ (at 25 ℃)
- Vapour density
- 5.08
- Relative density
- 1.471 (at 20 ℃)
- n-Octanol/water partition coefficient (Kow)
- 0.83
- Auto-ignition temperature
- 400 ℃
- Decomposition temperature
- 203 ℃
- Molecular weight
- 147.13
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Dye1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
1 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 2 studies
- High Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) according to EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay) - Studies Indicate No Significant Irritation
eye irritation: in vitro / ex vivo · Screening · OECD Guideline 438 (Isolated Chicken Eye Test Method for Identifying Ocular Corrosives and Severe Irritants) [before 26 July 2013] according to EU method B.48 (Isolated chicken eye test method for identifying occular corrosives and severe irritants) according to
Source: US EPA CompTox dashboard
Related literature
- Design, Synthesis and Biological Evaluation of Morpholinated Isatin-Quinoline Hybrids as Potential Anti-Breast Cancer Agents. · 2021
- Molecular docking and synthesis of N-alkyl-isatin-3-imino aromatic amine derivatives and their antileishmanial and cytotoxic activities · 2024
- Novel hydrazone‐isatin derivatives as potential EGFR inhibitors: Synthesis and in vitro pharmacological profiling · 2023
- Isatin come on the stage of CDK4/6 inhibitor · 2022
- Design, synthesis, and biological evaluation of novel morpholinated isatin–quinoline hybrids as potent anti‐breast cancer agents · 2021
Linked databases 24
- ASEAN Cosmetic Directive
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- EU restricted substances (Annex III)
- EU SCCS safety opinions
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic regulatory information 2 3 4
- NIST Chemistry WebBook
- PubChem 2
- Taiwan FDA cosmetic ingredients
- Taiwan FDA cosmetic regulations
- Tlooto literature search 2 3 4 5
- UK cosmetics regulations (OPSS)
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese