What is this ingredient?

미국 FDA 물질 등록 · UNII 376KTP06K8 · 등록명 AMILOXATE · 단일 화학물질

All ingredients

Ingredient Dictionary

ISOAMYL P-METHOXYCINNAMATE

Isoamyl p-Methoxycinnamate is the ester of isoamyl alcohol and p-methoxycinnamic acid.

Korean limit: 10%

ISOAMYL P-METHOXYCINNAMATE Molecular structure — Molecular structure

How much products actually contain

No product states its amount yet.

Of the products containing it, 34 list it before the 1% line and 0 after it (usually 1% or less).

Products using this ingredient

12 of 34 confirmed · likeliest to carry enough first · See all 34

Definition

US FDA substance register · UNII 376KTP06K8 · registered name AMILOXATE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Isoamyl p-Methoxycinnamate is the ester of isoamyl alcohol and p-methoxycinnamic acid. It conforms generally to the formula:

Cosmetic roles

Absorbs UV (including to protect the product)UV ABSORBERProtects colour and scent from lightLIGHT STABILIZERFilters UV to protect skin (sunscreen active)UV FILTER

Safety & regulatory references

Allowed UV filter: United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)

Argentina · Brazil

Maximum concentration permitted at final product : 10%

ASEAN

Maximum authorised concentration in the finished cosmetic product : 10%

Taiwan · China · South Korea

Maximum concentration : 10%

European Union

Maximum concentration in ready for use preparation : 10%

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex VI (allowed UV filters), entry 14 · maximum concentration 10%

Source: EU allowed UV filters (Annex VI)

Restriction VI/14 · Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name パラメトキシケイヒ酸イソアミル: 本品は、パラメトキシケイヒ酸とイソアミルアルコールとのエステルであり、次の化学式で表される。

Source: JCIA labelling names (Japan)

Names & identifiers

ISOAMYL P-METHOXYCINNAMATEINCI2-Propenoic acid, 3-(4-methoxyphenyl)-, 3-methylbutyl esterSynonym이소아밀p-메톡시신나메이트Korean label name (MFDS standard)パラメトキシケイヒ酸イソアミルJapanese labelling name

CAS No.chemical registry number: 71617-10-2
EC No.EU chemical inventory number: 275-702-5
DTXSIDUS EPA chemical ID: DTXSID1046055
DTXCIDUS EPA compound ID: DTXCID9026055

IUPAC: 3-Methylbutyl 3-(4-methoxyphenyl)prop-2-enoate
Molecular formula: C15H20O3
Molecular weight: 248.322 g/mol

Measured properties

Appearance: liquid
Melting/freezing point: 3.5 ℃((EU Method A.1))
Flash point: 194 ℃((99.5 kPa)(EU Method A.9, GLP))
Vapour pressure: 0.0066 ㎩ ((25 °C)(EU Method A.4))
Water solubility: 0.8 ㎎/ℓ ((EU Method A.6))
Relative density: 1.04 ((20 °C)(EU Method A.3))
n-Octanol/water partition coefficient (Kow): 4.78(25 °C, pH&amp, gt, 7.62 &amp, lt, 8.09)(EU Method A.8)
Auto-ignition temperature: 430 ℃ ((EU Method A.15, GLP))
Viscosity: 19.1 cP ((dynamic) (40 °C)(OECD Test Guideline 114))
Molecular weight: 248.3175

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 3 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

UV stabilizer3

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

2 skin studies and 2 eye studies are on record.

Classed as low2

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 4 studies

Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) according to EU Method B.6 (Skin Sensitisation)
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to
Studies Indicate No Significant Irritation
eye irritation: in vitro / ex vivo · Screening · other guideline: According to ICCVAM recommended HET-CAM Method Protocol (Nov. 2006) according to
Studies Indicate No Significant Irritation
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 437: "Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants", 2009 according to