Isoeugenol is a phenylpropanoid that is an isomer of eugenol in which the allyl substituent is replaced by a prop-1-enyl group.
How much products actually contain
No product states its amount yet.
Of the products containing it, 3 list it before the 1% line and 36 after it (usually 1% or less).
Products using this ingredient
12 of 39 confirmed · likeliest to carry enough first · See all 39
The Body ShopThe Body Shop Black Musk Fragrance Mist
The Body ShopThe Body Shop Glowing Cherry Blossom Body Mist
Nails.INCNails.INC Hint of Chill Nourishing Lip Balm
Body FantasiesBody Fantasies White Musk Body Spray 236ml
OUAIOUAI Hair & Body Fragrance Mist St. Barts Scent
OUAIOUAI Hair & Body Fragrance Mist St. Barts Scent - Travel
Calvin KleinCK One/Be/Moisturizer/Essence Perfume Intense/Mist
Calvin KleinCK One EDT (Single/Set)
HEY,TOMBlack Knight Body Spray
MoroccanoilIntense Curl Cream 75ml
MORNIGHTBody Perfume Spray Herb & Mills
MORNIGHTBody Perfume Spray Fig & Vanilla
Definition
Isoeugenol is a phenylpropanoid that is an isomer of eugenol in which the allyl substituent is replaced by a prop-1-enyl group. It has a role as a sensitiser and an allergen. It is an alkenylbenzene and a phenylpropanoid. It is functionally related to a guaiacol.
Source: PubChem
US FDA substance register · UNII 5M0MWY797U · registered name ISOEUGENOL · mixture
Cosmetic roles
Safety & regulatory references
- Restricted
- International fragrance standard (IFRA) · United Kingdom
Source: EU Cosmetics Regulation · IFRA fragrance standards · MFDS (Korea) cosmetic regulatory information · UK cosmetics regulations (OPSS)
European Union
- Product Type, body parts : (a) Oral products (b) Other products
- Maximum concentration in ready for use preparation : b) 0,02 %
- Other : (a) (b) The presence of the substance must be indicated in the list of ingredients referred to in Article 19(1)(g) when its concentration exceeds: — 0,001 % in leave-on products — 0,01 % in rinse-off products
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Restriction III/73
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name イソオイゲノール: 本品は、次の化学式で表されるフェノール誘導体である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 5912-86-7
- CAS No.chemical registry number
- 5932-68-3
- CAS No.chemical registry number
- 97-54-1
- EC No.EU chemical inventory number
- 227-678-2
- EC No.EU chemical inventory number
- 202-590-7
- EC No.EU chemical inventory number
- 227-633-7
- DTXSIDUS EPA chemical ID
- DTXSID7022413
- DTXCIDUS EPA compound ID
- DTXCID502413
- IUPAC
- 2-Methoxy-4-(prop-1-en-1-yl)phenol
- Molecular formula
- C10H12O2
- Molecular weight
- 164.204 g/mol
Measured properties
- Appearance
- liquid
- Melting/freezing point
- -10 ℃
- Initial boiling point and range
- 266 ℃
- Flash point
- &, gt, 100 ℃ (c.c.)
- Flammability (solid, gas)
- flammable
- Vapour pressure
- 0.0135 ㎜Hg
- Water solubility
- 810 ㎎/ℓ (at 25 ℃)
- Vapour density
- 5.67
- Relative density
- 1.080 (at 25 ℃)
- n-Octanol/water partition coefficient (Kow)
- 3.04
- Viscosity
- 7.476 cP (at 20 ℃)
- Molecular weight
- 164.21
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 171 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Fragrance164
- Flavouring and nutrient5
- Deodorizer1
- Processing aids not otherwise specified1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
7 skin studies and 2 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 9 studies
- Category 1
Skin Sensitization · Screening - Sh
Skin Sensitization · Authoritative - SkinIrr2
Skin Irritation · QSAR Predicted - SkinSens1
Skin Sensitization · QSAR Predicted - Category 6.5B (Category 1)
Skin Sensitization · Read Across - Category 6.3A (Category 2)
Skin Irritation · Read Across - Category 2
Skin Irritation · Screening - Category 2A
Eye Irritation · Screening - Category 6.4A (Category 2A)
Eye Irritation · Read Across
Source: US EPA CompTox dashboard
Related literature
- Targeting NRF2 With Isoeugenol: A Promising Small Molecule for Neurodegenerative, Metabolic, and Chronic Inflammatory Disorders · 2025
- Chemistry of Isoeugenol and Its Oxidation Products: Mechanism and Kinetics of Isoeugenol as a Skin Sensitizer. · 2023
- Development and Evaluation of Novel Encapsulated Isoeugenol-Liposomal Gel Carrier System for Methicillin-Resistant Staphylococcus aureus · 2023
- Is isoeugenol a pre-hapten? Characterization of a thiol-reactive oxidative byproduct of isoeugenol and potential implications for skin sensitization. · 2020
- Isoeugenol accelerates wound healing by attenuating pro-inflammatory markers and chemokine expression in diabetic mice · 2015
Linked databases 25
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI 2
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- IARC carcinogen classification
- IFRA fragrance standards
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UK cosmetics regulations (OPSS)
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- US National Toxicology Program reports
- Wikidata
- Wikipedia · English · Japanese · Chinese