What is this ingredient?

미국 FDA 물질 등록 · UNII 3404M9ZDTB · 등록명 ISOOCTYL THIOGLYCOLATE · 단일 화학물질

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Ingredient Dictionary

ISOOCTYL THIOGLYCOLATE

Definition

US FDA substance register · UNII 3404M9ZDTB · registered name ISOOCTYL THIOGLYCOLATE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Curls or straightens hairHAIR WAVING OR STRAIGHTENING

Safety & regulatory references

Restricted: China

Source: MFDS (Korea) cosmetic regulatory information

Argentina · Brazil

Field of application and/or use : Products for straightening or waving hair: 1. General use 2. Professional use
Maximum concentration permitted at final product : 1. 8% ready to use pH 6 to 9,5 2.11% ready to use pH 6 to 9.5 The percentages are calculated as thioglycolic acid
Other limitations and requirements : 1) and 2) In the USAGE must consist obligatorily the following information: - May cause sensitization by skin contact. - Avoid contact with eyes. - In case of contact with eyes, rinse immediately and thoroughly with water and consult a doctor. - Wear suitable gloves
Use conditions and warnings that must appear on the label : 1) and 2) Contains thioglycolate Follow the instructions Keep out of reach of children. For professional use only (if applicable)

ASEAN

Field of application and/or use : Hair waving or straightening products: 1. General use 2. Professional use
Maximum authorised concentration in the finished cosmetic product : 1. 8% ready for use at pH 6-9.5 2. 11% ready for use at pH 6-9.5 Percentages calculated as thioglycolic acid.
Other limitations and requirements : The directions for use drawn up in the national or official language(s) must obligatorily incorporate the following sentences: • May cause sensitisation in the event of skin contact. • Avoid contact with eyes. • In the event of contact with eyes, rinse immediately with plenty of water and seek medical advice. • Wear suitable gloves.
Conditions of use and warning which must be printed on the labels : • Contains thioglycolate. • Follow the instructions. • Keep out of reach of children. • For professional use only.

European Union

Product Type, body parts : Hair waving or straightening products
Maximum concentration in ready for use preparation : (a) 8% (b) 11% The abovementioned percentages are calculated as thioglycollic acid
Other : (a) General use ready for use pH 6 to 9.5 (b) Professional use ready for use pH 6 to 9.5
Wording of conditions of use and warnings : Conditions of use: (a) (b) May cause sensitization in the event of skin contact Avoid contact with eyes In the event of contact with eyes, rinse immediately with plenty of water and seek medical advice Wear suitable gloves Warnings: Contains thioglycolate Follow the instructions Keep out of reach of children (b) For professional use only

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Health Canada Cosmetic Ingredient Hotlist · prohibited in cosmetics

Source: Health Canada Cosmetic Ingredient Hotlist

Restriction III/2b · Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

Reviewed by CIR: Final Amended Report on the Safety Assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl Thioglycolate, Glyceryl Thioglycolate, Isooctyl Thioglycolate, Isopropyl Thioglycolate, Magnesium Thioglycolate, Methyl Thioglycolate, Potassium Thioglycolate, Sodium Thioglycolate, and Thioglycolic Acid

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Names & identifiers

ISOOCTYL THIOGLYCOLATEINCI아이소옥틸티오글라이콜레이트Korean label name (MFDS standard)Acetic acid, mercapto-, isooctyl esterSynonym

CAS No.chemical registry number: 25103-09-7
EC No.EU chemical inventory number: 246-613-9
DTXSIDUS EPA chemical ID: DTXSID1027841

Measured properties

Appearance: Liquid · Water-white liquid with a mild fruity odor, [Hawley] Colorless or pale yellow liquid, [HSDB] Clear white liquid, [Aldrich MSDS]
Odour: Faint fruity odor
Boiling point: 125 °C @ 17 mm Hg · BP: 80-88 °C (6 kPa)
Density: 0.9736 @ 25 °C · Density: 1.04 kg/l @ 20 °C
Melting/freezing point: ≤ 31 ℃
Initial boiling point and range: 124~125 ℃ (at 17mmHg)
Flash point: 120 ℃((c.c))
Vapour pressure: 0.0138 ㎜Hg (at 25℃ (est.))
n-Octanol/water partition coefficient (Kow): 3.68 ((est.))
Viscosity: 3.67 cP (at 20℃)
Molecular weight: 204.32

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 4 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Chain transfer agent1
Hair waving or straightening (EPA)1
Chemical reaction regulator1
Viscosity modifier1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

3 skin studies and 1 eye studies are on record.

Classed as highly irritating1Classed as moderate1

The studies disagree (the most common conclusion covers 50%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 4 studies

Moderate or Mild Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation)
SkinSens1
Skin Sensitization · QSAR Predicted
Moderate or Mild Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to