1-aminopropan-2-ol is any amino alcohol that is propan-2-ol substituted by an amino group at position 1.
How much products actually contain
No product states its amount yet.
Of the products containing it, 8 list it before the 1% line and 27 after it (usually 1% or less).
Products using this ingredient
12 of 35 confirmed · likeliest to carry enough first · See all 35
ESFOLIOClean Skin Volcanic Ash Cleansing Foam 150g
ESFOLIOEsfolio Aloe Vera Soothing Body Wash 500ml
ESFOLIOEsfolio Aloe Vera Soothing Cleansing Foam 150g
ESFOLIOEsfolio Coenzyme Q10 Fresh Cleansing Body Wash 500ml
ESFOLIOClean Skin Collagen Cleansing Foam 150g
ESFOLIOClean Skin Honey Cleansing Foam 150g
ESFOLIOEsfolio Hyaluronic Acid Houttuynia Cordata Cleansing Foam 100ml
ESFOLIOClean Skin Snail Cleansing Foam 150g
ESFOLIOClean Skin Milk Cleansing Foam 150g
ESFOLIOClean Skin Rice Cleansing Foam 150g
R+CoR+Co LABYRINTH 3-in-1 Texturizing Shampoo + Conditioner + Styler
Paul MitchellPaul Mitchell Platinum Plus Deep Violet Shampoo
Definition
1-aminopropan-2-ol is any amino alcohol that is propan-2-ol substituted by an amino group at position 1. It has a role as an Escherichia coli metabolite. It is an amino alcohol and a secondary alcohol.
Source: PubChem
US FDA substance register · UNII UE40BY1BZW · registered name ISOPROPANOLAMINE · single chemical substance
Cosmetic roles
Safety & regulatory references
- Restricted or banned
- China · South Korea
Source: MFDS (Korea) cosmetic regulatory information
Argentina · Brazil
- Maximum concentration permitted at final product : Under maximum secondary amine: 0.5%
- Other limitations and requirements : No use with nitrosating systems. Minimum 99% -Pureza. Maximum -Tenor of secondary amines in raw materials 0.5%. Maximum nitrosamine -Tenor: 50 ug / kg. -Envasar / Nitrite - free store in containers.
ASEAN
- Maximum authorised concentration in the finished cosmetic product : Maximum secondary amine content: 0.5%
- Other limitations and requirements : • Do not use with nitrosating systems • Minimum purity: 99% • Maximum secondary amine content: 0.5% (applies to raw materials) • Maximum nitrosamine content: 50 μg/kg • Keep in nitrite-free containers
European Union
- Maximum concentration in ready for use preparation : Maximum secondary amine content: 0.5%
- Other : - Do not use with nitrosating systems - Minimum purity: 99% - Maximum secondary amine content: 0.5% (applies to raw materials) - Maximum nitrosamine content: 50 microgram/kg - Keep in nitrite-free containers
Source: MFDS (Korea) cosmetic regulatory information
Korea’s toxic-substance GHS classification: Danger · H314 (category 1B)
Restriction III/61
Source: EU CosIng ingredient list
Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments - 2004/2005
Reviewed by CIR: Extended Re-review Summary: Safety Assessment of Diisopropanolamine, Triisopropanolamine, Isopropanolamine, and Mixed Isopropanolamines
Reviewed by CIR: Final Report on the Safety Assessment of Diisopropanolamine, Triisopropanolamine, Isopropanolamine, and Mixed Isopropanolamine
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name イソプロパノールアミン: 本品は、次の化学式で表されるアルカノールアミンである。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 78-96-6
- EC No.EU chemical inventory number
- 201-162-7
- DTXSIDUS EPA chemical ID
- DTXSID9021764
- DTXCIDUS EPA compound ID
- DTXCID901764
- IUPAC
- 1-Aminopropan-2-ol
- Molecular formula
- C3H9NO
- Molecular weight
- 75.111 g/mol
Measured properties
- Appearance
- liquid
- Colour
- colourless
- Melting/freezing point
- -2 ℃
- Initial boiling point and range
- 159.5 ℃
- Flash point
- 77 ℃
- Upper/lower flammability or explosive limits
- 10.4 / 1.9
- Vapour pressure
- 0.47 ㎜Hg (at 25℃)
- Water solubility
- 1000000 ㎎/ℓ
- Vapour density
- 2.6 (air=1)
- Relative density
- 0.96 (water=1)
- n-Octanol/water partition coefficient (Kow)
- -0.96
- Auto-ignition temperature
- 374 ℃
- Molecular weight
- 75.11
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 48 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Solvent10
- Chelating agent9
- Cleaning agent8
- pH regulating agent8
- Lubricating agent3
- Surfactant (surface active agent)3
- Intermediate2
- Flotation agent1
4 other uses
- Flavouring and nutrient1
- Emulsifier1
- Dispersing agent1
- Biocide1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
5 skin studies and 2 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 7 studies
- Category 8.2C (Category 1C)
Skin Irritation · Read Across - Skin Corr. 1B
Skin Irritation · Authoritative - Not classified
Skin Sensitization · Screening - Skin corrosion - category 1B
Skin Irritation · Screening - Category 1
Skin Irritation · Screening - Category 8.3A (Category 1)
Eye Irritation · Read Across - Category 1
Eye Irritation · Screening
Source: US EPA CompTox dashboard
Related literature
- β-elemene Isopropanolamine Derivative LXX-8250 Induces Apoptosis Through Impairing Autophagic Flux via PFKFB4 Repression in Melanoma Cells · 2022
- Contact urticaria syndrome caused by patch testing with cefotiam hydrochloride · 1999
- 3: Final Report on the Safety Assessment of Diisopropanolamine, Triisopropanolamine, Isopropanolamine, and Mixed Isopropanolamine · 1987
- [Study of the decrease of antiseptic activity which 4,4'-diamidino-1,6-diphenoxyhexane diisethionate, isopropanolamine lauryl sulfate and hexachlorophene undergo following contact with the human skin or with blood]. · 1962
Linked databases 22
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3 4
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese