Isopropyl palmitate is a fatty acid ester obtained by the formal condensation of carboxy group of palmitic acid with propan-2-ol.
How much products actually contain
No product states its amount yet.
Of the products containing it, 249 list it before the 1% line and 59 after it (usually 1% or less).
Products using this ingredient
12 of 303 confirmed · likeliest to carry enough first · See all 303
make p:remUV Defense Me Calming Sun Stick
make p:remmake p:rem UV Defense Me Calming Sun Stick 20g
M·A·CM·A·C Hyper Real Fresh Canvas Cleansing Oil - 6.7 fl oz
Paul MitchellPaul Mitchell Dry Paste
Design EssentialsDesign Essentials Agave & Lavender Weightless Thermal Protectant Serum
Design EssentialsDesign Essentials Silk Essentials Thermal Strengthening Serum
Miss Jessie'sMiss Jessie's Gloss So Good - Hair Shine Spray
Johnson'sJohnson's Baby Bedtime Lotion 500ml (Aroma Scent)
MamondeAmazing Deep Mint Cleansing Balm 90ml
HanyulPure Artemisia Light Deep Cleansing Oil 200ml
MamondeAmazing Deep Mint Cleansing Balm 180ml
ATOPALMOutdoor Play Sun Stick 21g
Definition
Isopropyl palmitate is a fatty acid ester obtained by the formal condensation of carboxy group of palmitic acid with propan-2-ol. Metabolite observed in cancer metabolism. It has a role as a human metabolite. It is an isopropyl ester and a fatty acid ester. It is functionally related to a hexadecanoic acid.
Source: PubChem
US FDA substance register · UNII 8CRQ2TH63M · registered name Isopropyl palmitate · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments - 2002/2003
Reviewed by CIR: Safety Assessment of Alkyl Esters as Used in Cosmetics
Reviewed by CIR: Final Report on the Safety Assessment of Octyl Palmitate, Cetyl Palmitate and Isopropyl Palmitate
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name パルミチン酸イソプロピル: 本品は、パルミチン酸（＊）とイソプロパノール（＊）とのエステルであり、次の化学式で表される。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 142-91-6
- EC No.EU chemical inventory number
- 205-571-1
- DTXSIDUS EPA chemical ID
- DTXSID9027104
- DTXCIDUS EPA compound ID
- DTXCID507104
- IUPAC
- Propan-2-yl hexadecanoate
- Molecular formula
- C19H38O2
- Molecular weight
- 298.511 g/mol
Measured properties
- Appearance
- liquid
- Colour
- colourless
- Melting/freezing point
- 13.5 ℃
- Initial boiling point and range
- 196~205 ℃
- Flash point
- 165 ℃
- Vapour pressure
- 0.0000559 ㎜Hg (at 25C)
- Water solubility
- 0.00135 ㎎/ℓ (at 25C)
- Relative density
- 0.85 ()
- n-Octanol/water partition coefficient (Kow)
- 8.16 ()
- Molecular weight
- 298.57
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 74 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner43
- Fragrance9
- Binder5
- Viscosity modifier4
- Solvent3
- Anti-static agent3
- Emulsifier2
- Thickening agent2
3 other uses
- Flavouring and nutrient1
- Lubricating agent1
- Deodorizer1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
2 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 3 studies
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to
Source: US EPA CompTox dashboard
Related literature
- Intensified Process for Low Temperature Enzymatic Conversion of Biodiesel-Derived Methyl Palmitate to Isopropyl Palmitate Using a FAU Zeolite Membrane Reactor · 2026
- Development, characterization in vitro and in silico of coenzyme Q10 loaded myristic acid with different liquid lipids nanostructured lipid carriers · 2021
- Permeation study through bacterial cellulose membrane. · 2014
- Effects of isopropyl palmitate on the skin permeation of drugs. · 2006
- The hairless guinea‐pig as a model for treatment of acute irritation in humans · 2006
Linked databases 21
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3 4
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Chinese