Isopropylamine is a member of the class of alkylamines that is propane carrying an amino group at position 2.
Definition
Isopropylamine is a member of the class of alkylamines that is propane carrying an amino group at position 2. It is a primary aliphatic amine and a member of alkylamines. It is a conjugate base of an isopropylaminium.
Source: PubChem
US FDA substance register · UNII P8W26T4MTD · registered name Isopropylamine · single chemical substance
Cosmetic roles
Safety & regulatory references
- Restricted or banned
- China · South Korea
Source: MFDS (Korea) cosmetic regulatory information
Argentina · Brazil
- Maximum concentration permitted at final product : Under maximum secondary amine: 0.5%
- Other limitations and requirements : No use with nitrosating systems. Minimum 99% -Pureza. Maximum -Tenor of secondary amines in raw materials 0.5%. Maximum nitrosamine -Tenor: 50 ug / kg. -Envasar / Nitrite - free store in containers.
ASEAN
- Maximum authorised concentration in the finished cosmetic product : Maximum secondary amine content: 0.5%
- Other limitations and requirements : • Do not use with nitrosating systems • Minimum purity: 99% • Maximum secondary amine content: 0.5% (applies to raw materials) • Maximum nitrosamine content: 50 μg/kg • Keep in nitrite-free containers
European Union
- Maximum concentration in ready for use preparation : Maximum secondary amine content: 0.5%
- Other : - Do not use with nitrosating systems - Minimum purity: 99% - Maximum secondary amine content: 0.5% (applies to raw materials) - Maximum nitrosamine content: 50 microgram/kg - Keep in nitrite-free containers
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Restriction III/61
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 75-31-0
- EC No.EU chemical inventory number
- 200-860-9
- DTXSIDUS EPA chemical ID
- DTXSID2025682
- DTXCIDUS EPA compound ID
- DTXCID905682
- IUPAC
- Propan-2-amine
- Molecular formula
- C3H9N
- Molecular weight
- 59.112 g/mol
Measured properties
- Appearance
- liquid
- Colour
- colourless
- Odour threshold
- 0.504 ㎎/㎥
- pH
- 13.1 (50vol%, at 25℃)
- Melting/freezing point
- &, lt, ℃ (1013 hPa)
- Initial boiling point and range
- 32 ℃(1013hPa)
- Flash point
- ≤ ℃
- Upper/lower flammability or explosive limits
- 2.3 / 10 %
- Vapour pressure
- 63100 ㎩ (20℃)
- Water solubility
- &, gt, 50 other: (20℃, % [m/m])
- Vapour density
- 2.04
- Relative density
- 687.1kg/m³ (20℃)
- n-Octanol/water partition coefficient (Kow)
- 0.26
- Auto-ignition temperature
- 355 ℃ (1 016 hPa)
- Viscosity
- 0.47
- Molecular weight
- 59.11
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 6 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Flavouring and nutrient2
- pH regulating agent2
- Intermediate2
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
7 skin studies and 4 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 11 studies
- Skin corrosion/irritation - Category 1
Skin Irritation · Screening - Skin Irrit. 2
Skin Irritation · Authoritative - Classification not possible
Skin Sensitization · Screening - Category 1A
Skin Irritation · Screening - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - Category 8.2C (Category 1C)
Skin Irritation · Read Across - Corrosive
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to - Category 1
Eye Irritation · Screening - Category 8.3A (Category 1)
Eye Irritation · Read Across - Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to - Eye Irrit. 2
Eye Irritation · Authoritative
Source: US EPA CompTox dashboard
Related literature
- Allergic contact dermatitis caused by herbicide containing glyphosate‐isopropylamine salt · 2022
- Non‐occupational allergic contact dermatitis from epoxy resin in children's games · 2022
- Impact of Glyphosate on the Changes in the mRNA Expression of Neurotransmitters in Experimental Rats · 2022
- Skin Notations for Low-Molecular-Weight Amines: Development of a Testing Protocol with Isopropylamine as an Example · 2018
- Green nanoemulsion-laden glyphosate isopropylamine formulation in suppressing creeping foxglove (A. gangetica), slender button weed (D. ocimifolia) and buffalo grass (P. conjugatum). · 2013
Linked databases 19
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese