Isorhamnetin is a monomethoxyflavone that is quercetin in which the hydroxy group at position 3' is replaced by a methoxy group.
Definition
Isorhamnetin is a monomethoxyflavone that is quercetin in which the hydroxy group at position 3' is replaced by a methoxy group. It has a role as a metabolite, an anticoagulant and an EC 1.14.18.1 (tyrosinase) inhibitor. It is a monomethoxyflavone, a tetrahydroxyflavone and a 7-hydroxyflavonol. It is functionally related to a quercetin. It is a conjugate acid of an isorhamnetin(1-).
Source: PubChem
US FDA substance register · UNII 07X3IB4R4Z · registered name ISORHAMNETIN · single chemical substance
Cosmetic roles
Safety & regulatory references
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name イソラムネチン: 本品は、次の化学式で表される有機化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 480-19-3
- EC No.EU chemical inventory number
- 207-545-5
- DTXSIDUS EPA chemical ID
- DTXSID10197379
- DTXCIDUS EPA compound ID
- DTXCID70119870
- IUPAC
- 3,5,7-Trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one
- Molecular formula
- C16H12O7
- Molecular weight
- 316.265 g/mol
Measured properties
- Appearance
- Solid
- Melting point
- 311 - 314 °C
Values measured on the substance itself, not a specification for a commercial raw material.
Source: PubChem
What products actually use it for
What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Humectant1
Source: US EPA CompTox dashboard
Related literature
- Natural dual inhibitor isorhamnetin-3-O-neohespeidoside targets tyrosinase and MC1R for skin pigmentation management · 2025
- Unveiling the Anticancer Mechanisms of Isorhamnetin: A Mini Review · 2025
- Molecular Docking of Isorhamnetin as CYP1A1 Inhibitor in Skin Photoaging · 2018
- Network pharmacological mechanisms of Vernonia anthelmintica (L.) in the treatment of vitiligo: Isorhamnetin induction of melanogenesis via up-regulation of melanin-biosynthetic genes · 2017
- Isorhamnetin inhibits cell proliferation and induces apoptosis in breast cancer via Akt and mitogen-activated protein kinase kinase signaling pathways · 2015
Linked databases 15
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- MFDS (Korea) cosmetic ingredient register 2
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese