Isosorbide is an organic molecular entity.
Definition
US FDA substance register · UNII WXR179L51S · registered name ISOSORBIDE · single chemical substance
Isosorbide is an organic molecular entity.
Source: PubChem
Isosorbide is the organic compound that conforms to the formula.
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 652-67-5
- EC No.EU chemical inventory number
- 211-492-3
- EC No.EU chemical inventory number
- 211-492-3 (I)
- DTXSIDUS EPA chemical ID
- DTXSID5046196
- DTXCIDUS EPA compound ID
- DTXCID3026196
- IUPAC
- 1,4:3,6-Dianhydro-D-glucitol
- Molecular formula
- C6H10O4
- Molecular weight
- 146.142 g/mol
Measured properties
- Appearance
- Liquid, Dry Powder · CRYSTALS
- Boiling point
- 175
- Melting point
- 60-63 · 61-64 °C
- Solubility
- 29 mg/mL
- Melting/freezing point
- 61~64 ℃
- Water solubility
- 4714000 ㎎/ℓ
- n-Octanol/water partition coefficient (Kow)
- 0.91
- Molecular weight
- 146.14
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 3 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Humectant1
- Intermediate1
- Softener and conditioner1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
2 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 3 studies
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to other guideline: French Norm from AFNOR for chemicals : NF T 03-263 according to - Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) according to EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay) - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to other guideline: French Norm francaise ffrom AFNOR for chemicals : NF T 03-264 according to
Source: US EPA CompTox dashboard
Related literature
- Nature-Derived Epoxy Resin Monomers with Reduced Sensitizing Capacity—Isosorbide-Based Bis-Epoxides · 2023
- Isosorbide Diesters: Mechanistic Insights and Therapeutic Applications in Skin and Neuroinflammatory Disorders · 2025
- Synthesis and characterization of isosorbide derived polyols as highly effective humectants · 2010
- Solubilizing and Hydrotropic Properties of Isosorbide Monoalkyl- and Dimethyl-Ethers · 2009
- Isosorbide Dinitrate Spray as Therapeutic Strategy for Treatment of Chronic Venous Ulcers · 2008
Linked databases 17
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese