(2S,4R)-ketoconazole is a cis-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine which dioxolane moiety has (2S,4R)-configuration.
Definition
US FDA substance register · UNII R9400W927I · registered name Ketoconazole · single chemical substance
(2S,4R)-ketoconazole is a cis-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine which dioxolane moiety has (2S,4R)-configuration. It is an enantiomer of a (2R,4S)-ketoconazole.
Source: PubChem
Ketoconazole is the heterocyclic compound that conforms to the formula
Cosmetic roles
Safety & regulatory references
- Banned
- ASEAN · China · European Union · United Kingdom
- Restricted or banned
- ASEAN · China · European Union · South Korea
Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · UK cosmetics regulations (OPSS)
Argentina · Brazil
- Field of application and/or use : Products to combat dandruff.
- Maximum concentration permitted at final product : 1.0%
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
EU Cosmetics Regulation, Annex II (prohibited substances), entry 1528
Restriction II/1528
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 65277-42-1
- EC No.EU chemical inventory number
- 265-667-4
- DTXSIDUS EPA chemical ID
- DTXSID7029879
- DTXCIDUS EPA compound ID
- DTXCID301437106
- IUPAC
- 1-{4-[4-({(2R,4S)-2-(2,4-Dichlorophenyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolan-4-yl}methoxy)phenyl]piperazin-1-yl}ethan-1-one
- Molecular formula
- C26H28Cl2N4O4
- Molecular weight
- 531.43 g/mol
What products actually use it for
What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Anti-dandruff (EPA)1
Source: US EPA CompTox dashboard
Related literature
Linked databases 16
- ASEAN Cosmetic Directive
- ChEBI
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- EU prohibited substances (Annex II)
- EU SCCS safety opinions 2
- Korea toxic substances GHS register (NIER)
- MFDS (Korea) cosmetic regulatory information 2 3 4
- PubChem
- Tlooto literature search 2 3 4 5
- UK cosmetics regulations (OPSS)
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata