Ingredient Dictionary

LIDOCAINE

Lidocaine is the monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.

Definition

Lidocaine is the monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline. It has a role as a xenobiotic, a local anaesthetic, an anti-arrhythmia drug, an environmental contaminant and a drug allergen. It is a member of benzenes, a monocarboxylic acid amide and a tertiary amino compound. It is functionally related to a glycinamide.

Source: PubChem

US FDA substance register · UNII 98PI200987 · registered name Lidocaine · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

No declared roleNOT REPORTED

Safety & regulatory references

Banned: Argentina · ASEAN · Brazil · Canada · China · European Union · South Korea · Taiwan · United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · Health Canada Cosmetic Ingredient Hotlist · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)

EU Cosmetics Regulation, Annex II (prohibited substances), entry 399

Source: EU prohibited substances (Annex II)

Health Canada Cosmetic Ingredient Hotlist · prohibited in cosmetics

Source: Health Canada Cosmetic Ingredient Hotlist

Restriction II/399

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Names & identifiers

LIDOCAINEINCI리도카인Korean label name (MFDS standard)

CAS No.chemical registry number: 137-58-6
EC No.EU chemical inventory number: 205-302-8
DTXSIDUS EPA chemical ID: DTXSID1045166
DTXCIDUS EPA compound ID: DTXCID9025166

IUPAC: N-(2,6-Dimethylphenyl)-N~2~,N~2~-diethylglycinamide
Molecular formula: C14H22N2O
Molecular weight: 234.343 g/mol

Measured properties

Appearance: Solid · Needles from benzene or alcohol
Odour: Characteristic odor · odourless
Boiling point: 159-160 °C at 2.00E+00 mm Hg · BP: 180-182 °C at 4 mm Hg, 159-160 °C at 2 mm Hg
Melting point: 68.5 °C · 68 °C
Solubility: 4100 mg/L (at 30 °C) · VERY SOL IN ALC, SOL IN CHLOROFORM, INSOL IN ETHER, WHITE CRYSTALLINE POWDER /LIDOCAINE HYDROCHLORIDE/
Stability: Commercially available solutions of lidocaine hydrochloride in 5% dextrose usually are stable for 18 months after the date of manufacture. Commercially available solutions of lidocaine hydrochloride in 5% dextrose may be provided in plastic containers. · Stable under recommended storage conditions.
Dissociation constant: 7.928 · 7.95
Melting/freezing point: 68.5 ℃
Initial boiling point and range: 180~182 ℃
Water solubility: 4100 ㎎/ℓ (exp)
n-Octanol/water partition coefficient (Kow): 2.26
Molecular weight: 234.3373

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Pharmaceutical (EPA)1
No specific technical function1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

5 skin studies and 2 eye studies are on record.

Classed as moderate1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 7 studies

Category 6.3A (Category 2)
Skin Irritation · Read Across
Classification not possible
Skin Irritation · Screening
Category 6.5B (Category 1)
Skin Sensitization · Read Across
Category 1
Skin Sensitization · Screening
SkinIrr2
Skin Irritation · QSAR Predicted
Category 6.4A (Category 2A)
Eye Irritation · Read Across
Classification not possible
Eye Irritation · Screening