Lithium Carbonate can cause developmental toxicity according to state or federal government labeling requirements.
Definition
Lithium Carbonate can cause developmental toxicity according to state or federal government labeling requirements.
Source: PubChem
US FDA substance register · UNII 2BMD2GNA4V · registered name LITHIUM CARBONATE · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 554-13-2
- EC No.EU chemical inventory number
- 209-062-5
- DTXSIDUS EPA chemical ID
- DTXSID1023784
- DTXCIDUS EPA compound ID
- DTXCID703784
- IUPAC
- Dilithium carbonate
- Molecular formula
- CLi2O3
- Molecular weight
- 73.89 g/mol
Measured properties
- Appearance
- Lithium carbonate appears as a white powder. Strong irritant when dissolved in water. · Large Crystals, Dry Powder
- Boiling point
- 1336 · Decomposes at 1300 °C
- Melting point
- 180.5 · 723 °C
- Solubility
- 100mM · Solubility in water (wt%): 1.52 at 0 °C, 1.31 at 20 °C, 1.16 at 40 °C, 1.00 at 60 °C, 0.84 at 80 °C, 0.71 at 100 °C
- Density
- 2.11 g/cu cm · 2.1 g/cm³
- Colour
- white
- pH
- 11.2
- Melting/freezing point
- 723 ℃
- Initial boiling point and range
- 1310 ℃
- Vapour pressure
- (9.1E-015mmHg 25℃, est.)
- Water solubility
- 1.3 g/100㎖
- Relative density
- 2.1
- n-Octanol/water partition coefficient (Kow)
- -6.19 (est.)
- Molecular weight
- 73.9
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 113 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Chemical reaction regulator98
- Processing aids not otherwise specified4
- Intermediate2
- pH regulating agent2
- Surface modifier2
- Corrosion inhibitor1
- Hair waving or straightening (EPA)1
- Filler1
2 other uses
- Sealant (barrier)1
- Crystal growth modifiers (nucleating agents)1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
4 skin studies and 4 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 8 studies
- Not classified
Skin Irritation · Screening - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) 1981 according to EU Method B.6 (Skin Sensitisation) 1987 according to EPA OPP 81-6 (Skin Sensitisation) 1984 - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) 1981 equivalent or similar to - Classification not possible
Skin Sensitization · Screening - Serious eye damage/eye irritation - Category 2B
Eye Irritation · Screening - Category 6.4A (Category 2A)
Eye Irritation · Read Across - Category 2B
Eye Irritation · Screening - Severe Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to
Source: US EPA CompTox dashboard
Related literature
- Analysis of the Decrement of Renal Weights in Adult Male Rats after Long Term Lithium Carbonate Ingestion · 2024
- Effect of rapamycin and lithium carbonate on depression-like behavior and anxiety in skin melanoma · 2022
- Exacerbation of Psoriasis Confirmed By Drug Challenge Test of Lithium Carbonate · 2016
- Effects of lithium carbonate (Li2CO3) on in‐vitro‐cultured normal human skin explants · 2000
- A CASE OF GRAVES' DISEASE USING LITHIUM CARBONATE IN PREOPERATIVE PREPARATION · 1994
Linked databases 18
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese