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Ingredients

Ingredient Dictionary

M-AMINOPHENOL

3-aminophenol is an aminophenol that is one of three amino derivatives of phenol which has the single amino substituent located meta to the phenolic -OH group.

Korean limit
2.0%
Molecular structure

How much products actually contain

No product states its amount yet.

Of the products containing it, 3 list it before the 1% line and 6 after it (usually 1% or less).

Products using this ingredient

9 of 9 confirmed · likeliest to carry enough first

Definition

3-aminophenol is an aminophenol that is one of three amino derivatives of phenol which has the single amino substituent located meta to the phenolic -OH group.

Source: PubChem

US FDA substance register · UNII L3WTS6QT82 · registered name m-Aminophenol · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Dyes hairHAIR DYEING

Safety & regulatory references

Restricted
South Korea · Taiwan · United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · Taiwan FDA cosmetic regulations · UK cosmetics regulations (OPSS)

ASEAN

  • Field of application and/or use : Hair dye substance in oxidative hair dye products. Use for dyeing eyelashes and eyebrows is not permitted.
  • Other limitations and requirements : After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.2% The direction for use “wear suitable gloves” must be included in label or leaflet text.
  • Conditions of use and warning which must be printed on the labels : The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past Do not use to dye eyelashes or eyebrows

China

  • Maximum concentration : 1%

European Union

  • Product Type, body parts : (a) Hair dye substance in oxidative hair dye products (b) Products intended for colouring eyelashes
  • Other : For (a) and (b): After mixing under oxidative conditions the maximum concentration applied to hair or eyelashes must not exceed 1,2 % (b) For professional use only
  • Wording of conditions of use and warnings : (a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy.Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary ‘black henna’ tattoo in the past.” (b) To be printed on the label: The mixing ratio. “For professional use only. This product can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase the risk of allergy. Eyelashes shall not be coloured if the consumer: — has a rash on the face or sensitive, irritated and damaged scalp, — has experienced any reaction after colouring hair or eyelashes,— has experienced a reaction to a temporary ‘black henna’ tattoo in the past. Rinse eyes immediately if product comes into contact with them.”

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Restriction III/217 · Other restriction: ban substances that deplete the ozone layer · SCCS opinion: Opinion on m-Aminophenol

Source: EU CosIng ingredient list

Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments: 2005/2006

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Final Report on the Safety Assessment of p-Aminophenol, m-Aminophenol, and o-Aminophenol

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Names & identifiers

M-AMINOPHENOLINCIm-아미노페놀Korean label name (MFDS standard)Phenol, 3-amino-Synonym
CAS No.chemical registry number
591-27-5
EC No.EU chemical inventory number
209-711-2
DTXSIDUS EPA chemical ID
DTXSID3024497
DTXCIDUS EPA compound ID
DTXCID704497
IUPAC
3-Aminophenol
Molecular formula
C6H7NO
Molecular weight
109.128 g/mol

Measured properties

Appearance
M-aminophenol appears as white crystals or off-white flakes. (NTP, 1992) · Large Crystals, Liquid
Boiling point
327 °F at 11 mmHg (NTP, 1992) · 164 °C at 11 mm Hg
Melting point
253 to 259 °F (NTP, 1992) · 123 °C
Solubility
1 to 10 mg/mL at 75 °F (NTP, 1992) · Freely soluble in amyl alcohol and hot water, soluble in 40 parts cold water, very slightly soluble in petroleum ether
Density
1.195 g/cu cm
Dissociation constant
pK1 = 4.37 at 20 °C, pK2 = 9.815 at 20 °C (conjugate acid)
Colour
white
Melting/freezing point
122~123 ℃
Initial boiling point and range
164 ℃(at 11 ㎜Hg)
Flash point
92 ℃
Vapour pressure
0.0096 ㎜Hg (at 25 ℃)
Water solubility
27000 ㎎/ℓ (at 20 ℃)
Relative density
1.195
n-Octanol/water partition coefficient (Kow)
0.21 (at pH 5.6)
Molecular weight
109.12

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 8 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

  • Dye5
  • Intermediate2
  • Monomers1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

8 skin studies and 3 eye studies are on record.

Classed as highly irritating4Classed as low4

The studies disagree (the most common conclusion covers 50%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 11 studies
  • Not classified
    Skin Irritation · Screening
  • Studies Indicate No Significant Irritation
    skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
  • High Frequency of Sensitization
    skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline:
  • Studies Indicate No Significant Irritation
    skin irritation: in vivo · Screening · other guideline: according to
  • High Frequency of Sensitization
    skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
  • Classification not possible
    Skin Sensitization · Screening
  • Sh
    Skin Sensitization · Authoritative
  • High Frequency of Sensitization
    skin sensitisation: in vivo (LLNA) · Screening · according to other guideline:
  • Classification not possible
    Eye Irritation · Screening
  • Studies Indicate No Significant Irritation
    eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
  • Studies Indicate No Significant Irritation
    eye irritation: in vivo · Screening · other guideline: according to

Source: US EPA CompTox dashboard

Related literature

Linked databases 27