Ingredient Dictionary

M-PHENYLENEDIAMINE

1,3-phenylenediamine is a phenylenediamine taht is benzene substituted at positions 1 and 3 with amino functions.

Definition

1,3-phenylenediamine is a phenylenediamine taht is benzene substituted at positions 1 and 3 with amino functions.

Source: PubChem

US FDA substance register · UNII OE624J2447 · registered name M-Phenylenediamine · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Dyes hairHAIR DYEING

Safety & regulatory references

Banned: Argentina · ASEAN · Brazil · China · European Union · South Korea · Taiwan · United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)

Korea’s toxic-substance GHS classification: Danger · H312 (category 4) · H319 (category 2) · H410 (category 1) · +4 more

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex II (prohibited substances), entry 1204

Source: EU prohibited substances (Annex II)

Restriction II/1204

Source: EU CosIng ingredient list

Reviewed by CIR: 40th Anniversary Overview and Rereview Summaries From 2011 to 2015

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Final Report on the Safety Assessment of m-Phenylenediamine and m-Phenylenediamine Sulfate

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Names & identifiers

M-PHENYLENEDIAMINEINCI1,3-BenzenediamineSynonymm-페닐렌디아민Korean label name (MFDS standard)

CAS No.chemical registry number: 108-45-2
DTXSIDUS EPA chemical ID: DTXSID4021137
DTXCIDUS EPA compound ID: DTXCID001137

IUPAC: Benzene-1,3-diamine
Molecular formula: C6H8N2
Molecular weight: 108.144 g/mol

Measured properties

Appearance: 1,3-phenylenediamine appears as colorless or white colored needles that turn red or purple in air. Melting point 64-66 C. Density 1.14 g / cm3. Flash point 280 F. May irritate skin and eyes. Toxic by skin absorption, inhalation or ingestion. Used in aramid fiber manufacture, as a polymer additive, dye manufacturing, as a laboratory reagent, and in photography. · Dry Powder, Other Solid, Large Crystals, CBI, Liquid
Boiling point: 540 to 543 °F at 760 mmHg (NTP, 1992) · 284-287 °C
Melting point: 145 to 147 °F (NTP, 1992) · 145-147 °F
Solubility: less than 1 mg/mL at 66 °F (NTP, 1992) · SOL IN WATER, METHANOL, ETHANOL, CHLOROFORM, ACETONE, DIMETHYLFORMAMIDE, METHYL ETHYL KETONE, DIOXANE, SLIGHTLY SOL IN ETHER, CARBON TETRACHLORIDE, ISOPROPANOL, DIBUTYL PHTHALATE. VERY SLIGHTLY SOL IN BENZENE, TOLUENE, XYLENE, BUTANOL.
Density: 1.0696 at 136 °F (NTP, 1992) - Denser than water, will sink · 1.0096 g/cu cm at 58 °C
Stability: UNSTABLE IN AIR
Dissociation constant: pKa = 4.98 at 25 °C (conjugate acid) · pKa1 = 2.65, pKa2 = 4.88 at 25 °C
Melting/freezing point: 62.5 ℃
Initial boiling point and range: 284~287 ℃
Flash point: 187 ℃(c.c.)
Vapour pressure: 133 ㎩ (99.8℃)
Water solubility: 23.8 g/100㎖ (20℃)
Vapour density: 3.7
Relative density: 1.07 (58℃)
n-Octanol/water partition coefficient (Kow): -0.33
Auto-ignition temperature: 560 ℃

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 12 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Processing aids not otherwise specified3
Intermediate2
Dye2
Adhesion/cohesion promoter2
Flame retardant1
Hardener1
Propellants, non-motive (blowing agents)1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

12 skin studies and 7 eye studies are on record.

Classed as moderate1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 19 studies

High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation)
Skin Sens. 1
Skin Sensitization · Screening
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: Guide to Labeling of Dangerous Substances published in the Official Journal of European Communiites (EEC Directive 93/21, Annex VI). according to
Skin Sens. 1
Skin Sensitization · Authoritative
Not classified
Skin Irritation · Screening
Category 1
Skin Sensitization · Screening
Sh
Skin Sensitization · Authoritative
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: Consumer Product Safety Commission of the U.S.A. in The Code of Federal Regulations, Title 16, Section 1500.41 according to
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline: MAFF Japan, 59 NohSan No. 4200, 1985 according to OECD Guideline 406 (Skin Sensitisation) according to other guideline: EEC 92/69 - Annex 5- Part B.6 (1992) - 93/21 (1993) according to EPA OPP 81-6 (Skin Sensitisation)
High Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · equivalent or similar to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation)
Category 6.5B (Category 1)
Skin Sensitization · Read Across
Category 6.4A (Category 2A)
Eye Irritation · Read Across
Eye Irrit. 2
Eye Irritation · Authoritative
Category 2
Eye Irritation · Screening
Eye Irrit. 2
Eye Irritation · Screening
Severe Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: Consumer Product Safety Commission of the U.S.A. in The Code of Federal Regulations, Title 16, Section. 1500.42 equivalent or similar to
Severe Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to