Madecassic acid is a pentacyclic triterpenoid that is ursane substituted by a carboxy group at position 28 and hydroxy groups at positions 2, 3, 6 and 23 (the 2alpha,3beta,6beta stereoisomer).
How much products actually contain
169 products state the amountmedian 0.000005%
- under 0.01% 158
- 0.01–0.1% 6
- 0.1–1% 5
- 1% or more 0
Amounts are mostly stated by products named after the ingredient, so they may lean towards token amounts.
Of the products containing it, 301 list it before the 1% line and 689 after it (usually 1% or less).
Products using this ingredient
12 of 989 confirmed · likeliest to carry enough first · See all 989
Centellian24Madeca Powder Tea Tree AC 6g0.5% stated
WISELYDerma Madecassic Acid Cream0.48% stated
Centellian24Madeca Cream Time Reverse 50ml0.48% stated
BRINGGREENZinc Teca Trouble Serum0.36% stated
Centellian24Madeca Cream Active Renew PDRN 50ml0.16% stated
Burt's BeesRes-Q Ointment Cica 17g0.03% stated
BRINGGREENTea Tree Cica SOS Spot Patch0.02% stated
TOUN28Haenam404 Hyaluron Cica Toner0.0014% stated
SOME BY MISOME BY MI AHA-BHA-PHA 30 Days Miracle Truecica Clear Pad 70 Pads0.0005% stated
SOME BY MISOME BY MI Snail Truecica Miracle Repair Toner 150ml0.0005% stated
PHYSIOGELPhysiogel CicaBalance For Men Calming Cream 70ml0.00035% stated
VELY VELYVELY VELY Cica Artemisia Repair Toner0.0002% stated
Definition
Madecassic acid is a pentacyclic triterpenoid that is ursane substituted by a carboxy group at position 28 and hydroxy groups at positions 2, 3, 6 and 23 (the 2alpha,3beta,6beta stereoisomer). It has a role as an antioxidant, an antibacterial agent, a hypoglycemic agent, an antineoplastic agent, an apoptosis inducer and a plant metabolite. It is a monocarboxylic acid, a pentacyclic triterpenoid and a tetrol. It is a conjugate acid of a madecassate. It derives from a hydride of an ursane.
Source: PubChem
US FDA substance register · UNII M7O1N24J82 · registered name MADECASSIC ACID · single chemical substance
Cosmetic roles
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name マデカシン酸: 本品は、次の化学式で表される有機化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 18449-41-7
- DTXSIDUS EPA chemical ID
- DTXSID70939838
- DTXCIDUS EPA compound ID
- DTXCID701775346
- IUPAC
- 2alpha,3beta,6beta,23-Tetrahydroxyurs-12-en-28-oic acid
- Molecular formula
- C30H48O6
- Molecular weight
- 504.708 g/mol
What products actually use it for
What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner1
Source: US EPA CompTox dashboard
Related literature
- Kandungan Bahan Aktif Daun Pegagan (Centella asiatica (L). Urb) Dan Pemanfaatannya Dalam Bidang Kesehatan · 2025
- Discovery and engineering of the asiaticoside, madecassoside and asiaticoside B biosynthetic pathway. · 2025
- Pharmacological effects of pentacyclic triterpenoids isolated from Centella asiatica · 2024
- Assessment of major centelloside ratios in Centella asiatica accessions grown under identical ecological conditions, bioconversion clues and identification of elite lines · 2022
- Assessment of major centelloside ratios in Centella asiatica accessions grown under identical ecological conditions, bioconversion clues and identification of elite lines · 2022
Linked databases 16
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- MFDS (Korea) cosmetic ingredient register 2
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English