Madecassoside is a triterpenoid saponin that is a trisaccharide derivative of madecassic acid.
- Skin barrier C
- Lines D
- Amount studies used
- about 0.1%
- When
- morning and evening
- Irritation
- low
Grades were set by reading this ingredient’s studies. They describe the ingredient, not every product that contains it.
How much products actually contain
189 products state the amountmedian 0.00001%5% at or above the amount studies used (about 0.1%)
- under 0.01% 157
- 0.01–0.1% 22
- 0.1–1% 10
- 1% or more 0
Amounts are mostly stated by products named after the ingredient, so they may lean towards token amounts.
Of the products containing it, 373 list it before the 1% line and 878 after it (usually 1% or less).
Where no amount is stated, a product listing it early reaches the study amount about 21% of the time, one listing it late about 3%.
Clinical evidence grade by skin concern
- C
- uncontrolled or multi-ingredient studies
- D
- lab work or a record only
Products using this ingredient
12 of 1,249 confirmed · likeliest to carry enough first · See all 1,249
ScinicScinic Skin Relief Madecassoside Ampoule0.5% stated · study amount
SidmoolDr. Troub Sebum Zero Centella Pact0.5% stated · study amount
MEDIHEALMadecassoside Derma Serum 50ml0.11% stated · study amount
Lazy SocietyCica After-shave Lotion0.1% stated · study amount
SidmoolUltra Facial Panthenol Cica Barrier Cream0.1% stated · study amount
KAHINatwie Sangseu Posica Relief Ampoule0.1% stated · study amount
Haruharu WonderHaruharu Wonder 5% Niacinamide Radiance Gel Cream / Unscented0.1% stated · study amount
Haruharu WonderHaruharu Wonder 5% Niacinamide Radiance Gel Cream / Unscented 40g0.1% stated · study amount
SOME BY MISOME BY MI Snail Truecica Miracle Repair Cream 60g0.1% stated · study amount
MEDIHEALMadecassoside Blemish Repair Derma Cream 500.1% stated · study amount
MORNIGHTCentella Hydrating Body Cream0.07% stated · below study amount
WISELYMadecassoside Serum0.06% stated · below study amount
Definition
Madecassoside is a triterpenoid saponin that is a trisaccharide derivative of madecassic acid. Isolated from Centella asiatica, it exhibits anti-inflammatory, antioxidant and antirheumatic activities. It has a role as an antioxidant, an antirheumatic drug, an anti-inflammatory agent, a vulnerary and a plant metabolite. It is a pentacyclic triterpenoid, a carboxylic ester, a triterpenoid saponin and a trisaccharide derivative. It is functionally related to a madecassic acid. It derives from a hydride of an ursane.
Source: PubChem
US FDA substance register · UNII CQ2F5O6YIY · registered name MADECASSOSIDE · single chemical substance
Cosmetic roles
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name マデカッソシド: 本品は、次の化学式で表される有機化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 34540-22-2
- EC No.EU chemical inventory number
- 252-076-1
- DTXSIDUS EPA chemical ID
- DTXSID40956057
- DTXCIDUS EPA compound ID
- DTXCID601776058
- IUPAC
- 6-Deoxy-alpha-L-mannopyranosyl-(1->4)-beta-D-glucopyranosyl-(1->6)-1-O-(2alpha,3beta,6beta,23-tetrahydroxy-28-oxours-12-en-28-yl)-beta-D-glucopyranose
- Molecular formula
- C48H78O20
- Molecular weight
- 975.132 g/mol
What products actually use it for
What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Antioxidant1
- Softener and conditioner1
Source: US EPA CompTox dashboard
Related literature
- <i>Centella asiatica</i> as a Model Biomass for Sustainable Production of Biochemicals via Green Extraction and Purification Technologies: A Comprehensive Field-to-Market Review. · 2026
- Madecassoside attenuated UVB irradiation-induced skin ferroptosis by targeting POR. · 2026
- Geroprotective Potential of <i>Centella asiatica</i>: Modulation of Cellular Aging. · 2026
- <i>Centella asiatica</i> phytochemical Madecassoside enhances skin wound healing and protects against UVB-induced keratinocyte damage. · 2026
- Madecassoside-functionalized platinum-based liposomes for sensitive skin: Enhancing rapid soothing and barrier homeostasis. · 2026
Linked databases 16
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- Europe PMC 2 3 4 5
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- MFDS (Korea) cosmetic ingredient register 2
- PubChem
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English