Melatonin is a member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group.
How much products actually contain
15 products state the amountmedian 0.025%
- under 0.01% 4
- 0.01–0.1% 5
- 0.1–1% 6
- 1% or more 0
Amounts are mostly stated by products named after the ingredient, so they may lean towards token amounts.
Of the products containing it, 13 list it before the 1% line and 21 after it (usually 1% or less).
Products using this ingredient
12 of 34 confirmed · likeliest to carry enough first · See all 34
MAXCLINICMelatonin Shot Ampoule0.35% stated
MAXCLINICMelatonin Shot Cream0.35% stated
MAXCLINICPremium Time Return Melatonin Cream0.25% stated
MAXCLINICTime Return Melatonin Cream0.25% stated
MAXCLINICTime Return Melatonin Cream0.25% stated
MAXCLINICTime Return Melatonin Cream Toner0.1% stated
RIRETRANEX Meladin Cream0.005% stated
Peace Out SkincarePeace Out Skincare Peace Out Wrinkles
MAXCLINICTime Return Melatonin Cream Mask (28g / 0.98 oz. x 4 Sheets)
ArocellMela TXA Sun Serum 40ml
Centellian24Madeca Mela Capture Ampoule Max 15ml (2-Pack)
Centellian24Expert Madeca Mela Capture Ampoule Max 15ml
Definition
Melatonin is a member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans. It has a role as a geroprotector, a hormone, a central nervous system depressant, an anticonvulsant, a radical scavenger, an immunological adjuvant, a mouse metabolite and a human metabolite. It is a member of acetamides and a member of tryptamines. It is functionally related to a tryptamine.
Source: PubChem
US FDA substance register · UNII JL5DK93RCL · registered name Melatonin · single chemical substance
Melatonin is the organic compound that conforms to the formula
Cosmetic roles
Safety & regulatory references
SCCS opinion: Opinion on Melatonin
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 73-31-4
- EC No.EU chemical inventory number
- 200-797-7
- DTXSIDUS EPA chemical ID
- DTXSID1022421
- DTXCIDUS EPA compound ID
- DTXCID002421
- IUPAC
- N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide
- Molecular formula
- C13H16N2O2
- Molecular weight
- 232.283 g/mol
Measured properties
- Appearance
- Solid · Pale yellow leaflets from benzene
- Melting point
- 117 °C · 116-118 °C
- Solubility
- In water, 2 g/L at 20 °C, 5 g/L at 50 °C · >34.8 [ug/mL] (The mean of the results at pH 7.4)
- Dissociation constant
- Melatonin has pKa of 16.51 and -0.69 and is uncharged in the entire pH-range
- Melting/freezing point
- 102 ℃
- Molecular weight
- 179.24
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Antioxidant2
Source: US EPA CompTox dashboard
Related literature
Linked databases 19
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- EU SCCS safety opinions
- Korea Cosmetic Association ingredient dictionary
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese