Menadione is a member of the class of 1,4-naphthoquinones that is 1,4-naphthoquinone which is substituted at position 2 by a methyl group.
How much products actually contain
25 products state the amountmedian 0.000004%
- under 0.01% 24
- 0.01–0.1% 1
- 0.1–1% 0
- 1% or more 0
Amounts are mostly stated by products named after the ingredient, so they may lean towards token amounts.
Of the products containing it, 18 list it before the 1% line and 109 after it (usually 1% or less).
Products using this ingredient
12 of 127 confirmed · likeliest to carry enough first · See all 127
MEDIPEELMEDIPEEL Vegan Vitamin Deep-Tox Cleansing Oil0.0001% stated
MEDIPEELMEDIPEEL [Makeup Deep Cleansing] Vegan Vitamin Deep-Tox Cleansing Oil 200ml0.0001% stated
MEDIPEELMEDIPEEL Algo-Tox Vita Cleanser 150ml0.0001% stated
ENOUGHReal Vita 8 Complex Pro Brighten-Up Ampoule0.00000001% stated
ENOUGHReal Vita 8 Essence0.00000001% stated
ENOUGHReal Vita 8 Eye Cream0.00000001% stated
AROMATICARosemary Root Enhancer 100ml
THE SAEMGolden Berry C Eye Cream
AROMATICATea Tree Purifying Tonic 100ml
SOME BY MISOME BY MI Yuja Niacin Brightening Moisture Gel Cream 100ml
Biome ActivateCleansing Tissue 30 Sheets
LAVIENLAVIEN Medinic Line Miracle Stem Sphingosome Filament
Definition
Menadione is a member of the class of 1,4-naphthoquinones that is 1,4-naphthoquinone which is substituted at position 2 by a methyl group. It is used as a nutritional supplement and for the treatment of hypoprothrombinemia. It has a role as an EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor, an antineoplastic agent, an angiogenesis inhibitor, a nutraceutical and a human urinary metabolite. It is a member of 1,4-naphthoquinones and a vitamin K.
Source: PubChem
US FDA substance register · UNII 723JX6CXY5 · registered name MENADIONE · single chemical substance
Cosmetic roles
Safety & regulatory references
Korea’s toxic-substance GHS classification: Warning · H400 (category 1)
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name メナジオン: 本品は、次の化学式で表される多環式芳香族化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 58-27-5
- EC No.EU chemical inventory number
- 200-372-6
- DTXSIDUS EPA chemical ID
- DTXSID4021715
- DTXCIDUS EPA compound ID
- DTXCID801715
- IUPAC
- 2-Methylnaphthalene-1,4-dione
- Molecular formula
- C11H8O2
- Molecular weight
- 172.183 g/mol
Measured properties
- Appearance
- Bright yellow solid with a very mild acrid odor, [Merck Index] · Solid
- Odour
- Very faint acrid odor · Nearly odorless
- Melting point
- 107 °C · 105-107 °C
- Solubility
- 160 mg/L (at 30 °C) · Slightly soluble in ethanol, acetic acid, and ligroin. Soluble in ethyl ether, benzene, chloroform, and sulfuric acid.
- Stability
- Stable in air, decomp by sunlight. ... Destroyed by alkalies and reducing agents. · STABLE IN QUINONE FORM.
- pH
- Alc soln is neutral to litmus
Values measured on the substance itself, not a specification for a commercial raw material.
Source: PubChem
What products actually use it for
What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Deodorizer1
Source: US EPA CompTox dashboard
Related literature
- Menadione Topical Lotion · 2020
- Scientific Opinion on the safety and efficacy of vitamin K3 (menadione sodium bisulphite and menadione nicotinamide bisulphite) as a feed additive for all animal species. · 2014
- Identification and Characterization of Menadione and Benzethonium Chloride as Potential Treatments of Pierce's Disease of Grapevines. · 2019
- Retraction: The Phosphatase Inhibitor Menadione (Vitamin K3) Protects Cells from EGFR Inhibition by Erlotinib and Cetuximab · 2013
- The Phosphatase Inhibitor Menadione (Vitamin K3) Protects Cells from EGFR Inhibition by Erlotinib and Cetuximab · 2011
Linked databases 18
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese