Definition
US FDA substance register · UNII IY191986AO · registered name Mercuric oxide · single chemical substance
Cosmetic roles
Safety & regulatory references
- Banned
- Argentina · ASEAN · Brazil · Canada · China · European Union · Japan · South Korea · Taiwan
Source: Health Canada Cosmetic Ingredient Hotlist · MFDS (Korea) cosmetic regulatory information
United States
- Specific Limitations and Comments : Mercury compounds are readily absorbed through the skin on topical application and tend to accumulate in the body. They may cause allergic reactions, skin irritation, or neurotoxic problems. The use of mercury compounds in cosmetics is limited to eye area products at no more than 65 parts per million (0.0065 percent) of mercury calculated as the metal and is permitted only if no other effective and safe preservative is available. All other cosmetics containing mercury are adulterated and subject to regulatory action unless it occurs in a trace amount of less than 1 part per million (0.0001 percent) calculated as the metal and its presence is unavoidable under conditions of good manufacturing practice
Source: MFDS (Korea) cosmetic regulatory information
Korea’s toxic-substance GHS classification: Danger · H400 (category 1) · H410 (category 1) · H373 (category 2) · +3 more
Health Canada Cosmetic Ingredient Hotlist · prohibited in cosmetics
Restriction II/221
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 21908-53-2
- EC No.EU chemical inventory number
- 244-654-7
- DTXSIDUS EPA chemical ID
- DTXSID4042125
- DTXCIDUS EPA compound ID
- DTXCID2022125
- IUPAC
- (Oxido)mercury
- Molecular formula
- HgO
- Molecular weight
- 216.59 g/mol
Measured properties
- Appearance
- Mercuric oxide, [solid] appears as red or orange-red odorless, dense crystalline powder or scales, yellow when finely powdered. Used as a chemical intermediate for mercury salts, organic mercury compounds, and chlorine monoxide, antiseptic in pharmaceuticals, component of dry cell batteries, pigment and glass modifier, fungicide, preservative in cosmetics, analytical reagent, formerly used in anti · Yellow, orange-yellow, or red crystals, Insoluble in water, [ICSC] Powder, [Sigma-Aldrich MSDS]
- Odour
- Odorless
- Melting point
- Decomposes at 932 °F (EPA, 1998) · 500 °C (decomp)
- Solubility
- 0.0053 G/100 CC WATER @ 25 °C · 0.0395 G/100 CC WATER @ 100 °C
- Density
- 11.1 at 39 °F (EPA, 1998) - Denser than water, will sink · 11.00-11.29 (Red), 11.03 @ 27.5 °C (Yellow)
- Stability
- DECOMPOSES ON EXPOSURE TO AIR · RED MERCURIC OXIDE: DECOMP ON EXPOSURE TO LIGHT INTO MERCURY & OXYGEN
Values measured on the substance itself, not a specification for a commercial raw material.
Source: PubChem
What products actually use it for
What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Biocide1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
2 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 3 studies
- Category 2
Skin Irritation · Screening - Category 1
Skin Sensitization · Screening - Category 2
Eye Irritation · Screening
Source: US EPA CompTox dashboard
Related literature
- Safety Aspects of Extemporaneous Prescriptions Prescribed by Latvian Healthcare Specialists. · 2021
- Case Report: Successful management of hepatic injury secondary to mercury (II) oxide poisoning in a Vulpes lagopus with tail gland infection · 2026
- Perception and management of Oestrus ovis human myiasis by physicians: Exploratory survey in an endemic area (Italy) · 2025
- Therapeutic Efficacy and Concomitant Toxicity of Hongsheng Dan in Enhancing Healing of Chronic Refractory Wounds in Rats. · 2025
- A critical review on Gandhakadya malahara · 2022
Linked databases 16
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- EU CosIng ingredient list 2
- Health Canada Cosmetic Ingredient Hotlist
- Korea toxic substances GHS register (NIER)
- MFDS (Korea) cosmetic regulatory information 2 3
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese