Methacrylic acid is an alpha,beta-unsaturated monocarboxylic acid that is acrylic acid in which the hydrogen at position 2 is substituted by a methyl group.
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含该成分的产品中，2 款将其列在 1% 线之前，0 款列在之后（通常不超过 1%）。
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定义
Methacrylic acid is an alpha,beta-unsaturated monocarboxylic acid that is acrylic acid in which the hydrogen at position 2 is substituted by a methyl group. It is functionally related to an acrylic acid. It is a conjugate acid of a methacrylate.
来源: PubChem
美国FDA 物质登记 · UNII 1CS02G8656 · 登记名称 Methacrylic Acid · 单一化学物质
化妆品中的作用
安全与法规参考
加拿大
- Conditions of Use by product type : (a) Cosmetics that contain more than 5% methacrylic acid (b) Other cosmetics
- Warnings and Cautionary Statements: (to the effect of) : (a) "This product contains methacrylic acid, is poisonous, is to be kept out of reach of children" and,"In the case of accidental ingestion, a Poison Control Centre or physician is to be contacted immediately."
来源: 韩国食药处 化妆品法规信息
韩国有毒物质 GHS 分类: 危险 · H311 (第3类) · H314 (第1A类) · H332 (第4类) · 另有 2 项
Other restriction: ban substances that deplete the ozone layer
来源: 欧盟 CosIng 成分清单
Reviewed by CIR: Final Report on the Safety Assessment of Methacrylic Acid
来源: 美国CIR 安全性评估
详细资料——标示名称、识别编号、物性、试验记录、文献
官方标示名称和定义
日本化妆品工业联合会标示名称 メタクリル酸: 本品は、次の化学式で表される有機化合物である。
来源: 日本化妆品工业联合会标示名称
别名和识别信息
- CAS No.化学物质登记号
- 79-41-4
- EC No.欧盟化学品目录编号
- 201-204-4
- DTXSID美国EPA化学品编号
- DTXSID3025542
- DTXCID美国EPA化合物编号
- DTXCID505542
- IUPAC
- 2-Methylprop-2-enoic acid
- 分子式
- C4H6O2
- 分子量
- 86.09 g/mol
实测物性
- 性状
- Methacrylic acid appears as a clear colorless liquid (or low-melting solid) with a pungent odor. Corrosive to metals and tissue. Flash point 170 °F. Melting point 61 °F. May polymerize exothermically if heated or contaminated. If the polymerization takes place inside a container, the container may rupture violently. Less dense than water. Vapors heavier than air. Used to make plastics. · Methacrylic acid, stabilized appears as a clear colorless liquid with a pungent odor. Corrosive to metals and tissue. Combustible. Flash point 170 °F. Melting point 61 °F. May polymerize if contaminated or heated. If polymerization takes place inside a closed container, the container may violently rupture. Less dense than water and is soluble in water. Vapors heavier than air. Used to make plastic
- 气味
- Acrid, repulsive odor
- 沸点
- 325 °F at 760 mmHg (NTP, 1992) · 325 °F at 760 mmHg (NIOSH, 2024)
- 熔点
- 61 °F (NTP, 1992) · 61 °F (NIOSH, 2024)
- 溶解性
- greater than or equal to 100 mg/mL at 63 °F (NTP, 1992) · 9 % at 77 °F (NIOSH, 2024)
- 密度
- 1.015 at 68 °F (USCG, 1999) - Denser than water, will sink · 1.02 (Liquid) (NIOSH, 2024) - Denser than water, will sink
- 稳定性
- Acrylic acid and methacrylic acid readily polymerize in the presence of light, heat and oxygen, and also under the action of oxidizing agents such as peroxides.
- 黏度
- 1.38 mPa.s at 24 °C · 1.38 (24℃, mPa s)
- 解离常数
- pKa = 4.65
- 颜色
- 无色
- 熔点/凝固点
- 16 ℃
- 初沸点和沸程
- 159~163 ℃
- 闪点
- 171 ℉
- 燃烧或爆炸范围上限/下限
- 8.8 / 1.6 %
- 蒸气压
- 0.99 ㎜Hg (25℃)
- 溶解度
- 89 (20℃, g/L)
- 蒸气密度
- 2.97
- 比重
- 1.0153 (20℃/4℃)
- 正辛醇/水分配系数（Kow）
- 0.93
- 分子量
- 86.09
这是对物质本身测得的数值。韩国安全保健公团（KOSHA）的资料仅供编写和审核安全数据表参考，并非原料商品的规格。
来源: PubChem · 韩国安全保健公团 安全数据表
产品实际使用的用途
这是向美国 EPA 申报含该成分的 23 款产品的用途。其中包括化妆品以外的产品，排在前几行的即为该成分的主要用途。
- Monomers6
- Intermediate3
- Adhesion/cohesion promoter3
- Processing aids not otherwise specified2
- Surfactant (surface active agent)2
- Binder2
- Elasticizer2
- Photosensitive agent1
其余用途 2 项
- Cleaning agent1
- Film former1
来源: 美国EPA CompTox
刺激与致敏试验记录
记录有皮肤试验 8 项、眼部试验 3 项。
试验结论基本一致（100%）。 这是对原料本身的试验记录，与成品中所含浓度下的刺激性不同。
查看全部 11 项试验
- Category 8.2B (Category 1B)
Skin Irritation · Read Across - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation) - Skin corrosion/irritation - Category 1A
Skin Irritation · Screening - Skin Corr. 1A
Skin Irritation · Authoritative - Skin corrosion - category 1A
Skin Irritation · Screening - Category 1A
Skin Irritation · Screening - Not classified
Skin Sensitization · Screening - Corrosive
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to other guideline: DOT Packing Group Classification according to - Category 1
Eye Irritation · Screening - Category 8.3A (Category 1)
Eye Irritation · Read Across - Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · other guideline: Draize according to
来源: 美国EPA CompTox
相关文献
- Sustainable Poly (Methacrylic Acid)/Nanocellulose Hydrogel for Controlled Simultaneous Release of Active Substances for Skin Protection · 2025
- Terbinafine-loaded biocompatible hydrogel patches composed of hydroxyethyl methacrylate and methacrylic acid with remarkable antifungal activities · 2025
- Solution Copolymerizations of N ‐Vinyl‐2‐Pyrrolidone with Acrylic Acid, Methacrylic Acid and Vinyl Acetate for Applications in Hair Cosmetics · 2020
- Cloisite-g-Methacrylic Acid Copolymer Nanocomposites by Graft from Method for Leather Processing · 2013
- Poly(methacrylic acid-co-methyl methacrylate) beads promote vascularization and wound repair in diabetic mice. · 2009
关联数据库 22
- 澳大利亚工业化学品名录（AICIS）
- 韩国安全保健公团 安全数据表
- 韩国化妆品协会成分词典
- 韩国食药处 化妆品法规信息 2 3 4
- 韩国食药处 化妆品原料成分 2
- 韩国有毒物质 GHS 信息（环境公团）
- 加拿大禁用·限用成分清单
- 美国CIR 安全性评估 2
- 美国EPA 化学品数据库（DSSTox）
- 美国EPA CompTox 2
- 美国FDA 物质登记（GSRS）
- 美国FDA 物质识别码（UNII）
- 欧盟 CosIng 成分清单 2
- 日本化妆品工业联合会标示名称
- ChEBI
- ChEMBL
- NIST 化学网络手册
- PubChem 2
- Tlooto 学术文献检索 2 3 4 5
- UniChem 化学物质统一 ID
- Wikidata
- Wikipedia · 韩语 · 英语 · 日语 · 中文