Methionine is a sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.
How much products actually contain
10 products state the amountmedian 0.000012%
- under 0.01% 10
- 0.01–0.1% 0
- 0.1–1% 0
- 1% or more 0
Amounts are mostly stated by products named after the ingredient, so they may lean towards token amounts.
Of the products containing it, 93 list it before the 1% line and 422 after it (usually 1% or less).
Products using this ingredient
12 of 514 confirmed · likeliest to carry enough first · See all 514
ElastineAmino Peptide Weak Acid Protein High Nutrition Shampoo Pear & Freesia Scent0.000029% stated
BiothermBiosource Dual-Action Toner 400ml
RootecaRooteca Root Enhancing Ampoule Shampoo 200ml (Single)
DALEAFGlam Styling Fixer Special Set
DALEAFGlam Styling Fixer 200ml
BENTONBenton Honest Eyelash Serum
Peach & LilyPeach & Lily Super Oasis Concentrated Serum
Peach & LilyPeach & Lily Velvet Biome Smoothing Silky Ointment
Peach & LilyPeach & Lily Copper Peptide Pro Firming Serum
ElastinePerfume Conditioner Pure Breeze
Peach & LilyPeach & Lily Rescue Party Barrier Restore Serum
ElastineMarine Collagen Volume Treatment
Definition
Methionine is a sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4. It has a role as a Saccharomyces cerevisiae metabolite, a plant metabolite, an Escherichia coli metabolite, a Daphnia magna metabolite and an algal metabolite. It is a sulfur-containing amino acid and an alpha-amino acid. It is functionally related to a butyric acid. It is a conjugate base of a methioninium. It is a conjugate acid of a methioninate. It is a tautomer of a methionine zwitterion.
Source: PubChem
US FDA substance register · UNII 73JWT2K6T3 · registered name RACEMETHIONINE · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Reviewed by CIR: Safety Assessment of alpha-Amino Acids as Used in Cosmetics
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name メチオニン: 本品は、次の化学式で表されるアミノ酸である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 63-68-3
- CAS No.chemical registry number
- 59-51-8
- EC No.EU chemical inventory number
- 200-562-9
- EC No.EU chemical inventory number
- 206-483-6
- EC No.EU chemical inventory number
- 200-432-1
- DTXSIDUS EPA chemical ID
- DTXSID9020821
- DTXCIDUS EPA compound ID
- DTXCID50821
- IUPAC
- Methionine
- Molecular formula
- C5H11NO2S
- Molecular weight
- 149.21 g/mol
Measured properties
- Appearance
- Solid, [Merck Index] Colorless or white solid, [ICSC] White powder, [Sigma-Aldrich MSDS] · Solid
- Boiling point
- 300.00 to 301.00 °C. @ 760.00 mm Hg
- Melting point
- 281 °C
- Solubility
- 32.7 mg/mL at 25 °C · Solubility in water, g/100ml at 20 °C: 4.8
- Density
- Relative density (water = 1): 1.3
- Colour
- white
- Melting/freezing point
- 266-267 ℃
- Initial boiling point and range
- 480 ℃
- Flash point
- 305 ℃
- Vapour pressure
- 0.000000129 ㎜Hg
- Water solubility
- 29100 ㎎/ℓ (at 20℃)
- Relative density
- 1.3
- n-Octanol/water partition coefficient (Kow)
- -2.410
- Decomposition temperature
- 281 ℃
- Molecular weight
- 149.21
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 20 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner6
- Flavouring and nutrient6
- Fragrance2
- Anti-static agent2
- Pharmaceutical (EPA)2
- Chemical reaction regulator1
- Stabilizing agent1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
1 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 2 studies
- Category 6.3A (Category 2)
Skin Irritation · Read Across - Category 6.4A (Category 2A)
Eye Irritation · Read Across
Source: US EPA CompTox dashboard
Related literature
- Dimethylglycine, a methionine metabolite, participates in the suppressive effect of methionine on 1-fluoro-2,4-dinitrobenzene-induced dermatitis. · 2023
- Methionine can subside hair follicle development prejudice of heat‐stressed rex rabbits · 2022
- Safety and efficacy of zinc chelate of methionine sulfate for all animal species · 2017
- The role of methionine in ethylmalonic encephalopathy with petechiae. · 2004
- Metabolism of methionine in tissues of cattle in vitro · 1998
Linked databases 20
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese