Ingredient Dictionary

METHOXYDIGLYCOL

2-(2-methoxyethoxy)ethanol is a hydroxypolyether that is the monomethyl ether derivative of diethylene glycol.

Definition

2-(2-methoxyethoxy)ethanol is a hydroxypolyether that is the monomethyl ether derivative of diethylene glycol. It has a role as a solvent and a teratogenic agent. It is a glycol ether, a diether and a hydroxypolyether. It is functionally related to a diethylene glycol.

Source: PubChem

US FDA substance register · UNII 465DDJ8G8K · registered name Methoxydiglycol · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Base that dissolves other ingredientsSOLVENTGives the product a scentPERFUMINGListed as a fragrance-composition material (not a claim that it adds scent)FRAGRANCEAdjusts thicknessVISCOSITY CONTROLLING

Safety & regulatory references

Banned: Argentina · ASEAN · Brazil · Canada · China · European Union · South Korea · United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · Health Canada Cosmetic Ingredient Hotlist · MFDS (Korea) cosmetic regulatory information · UK cosmetics regulations (OPSS)

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex II (prohibited substances), entry 1000

Source: EU prohibited substances (Annex II)

Health Canada Cosmetic Ingredient Hotlist · prohibited in cosmetics

Source: Health Canada Cosmetic Ingredient Hotlist

Restriction II/1000

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name メトキシジグリコール: 本品は、次の化学式で表される脂肪族エーテルアルコールである。

Source: JCIA labelling names (Japan)

Names & identifiers

METHOXYDIGLYCOLINCI메톡시다이글라이콜Korean label name (MFDS standard)Ethanol, 2-(2-methoxyethoxy)-SynonymメトキシジグリコールJapanese labelling name

CAS No.chemical registry number: 111-77-3
EC No.EU chemical inventory number: 203-906-6
DTXSIDUS EPA chemical ID: DTXSID3025049
DTXCIDUS EPA compound ID: DTXCID305049

IUPAC: 2-(2-Methoxyethoxy)ethan-1-ol
Molecular formula: C5H12O3
Molecular weight: 120.148 g/mol

Measured properties

Appearance: Diethylene glycol monomethyl ether is a colorless liquid with a sweet odor. Floats and mixes with water. (USCG, 1999) · Liquid
Odour: Slight or pleasant smell /Solvents/ · Ether-like odor
Boiling point: 381 °F at 760 mmHg (NTP, 1992) · 193 °C
Melting point: -94 °F (NTP, 1992) · Less than -84 °C
Solubility: greater than or equal to 100 mg/mL at 66 °F (NTP, 1992) · Miscible /1X10+6 mg/L/ with water
Density: 1.025 at 68 °F (USCG, 1999) - Denser than water, will sink · 1.035 g/cu cm at 20 °C
Viscosity: 3.48 mPa.s (=cPa) at 25 °C
Melting/freezing point: &amp, lt, -84 ℃
Initial boiling point and range: 193 ℃
Flash point: 87 ℃(closed cup)
Upper/lower flammability or explosive limits: 18.1 / 1.6 %
Vapour pressure: 0.25 ㎜Hg (25℃)
Vapour density: 4.14
Relative density: 1.035
n-Octanol/water partition coefficient (Kow): -1.18 (est.)
Auto-ignition temperature: 215 ℃
Molecular weight: 120.15

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 44 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Solvent19
Surface modifier4
Hydraulic fluids3
Fragrance3
Processing aids not otherwise specified2
Fuel2
Intermediate2
Flow promoter2

6 other uses

Fuel agents2
Film former1
Chemical reaction regulator1
Cleaning agent1
Deodorizer1
Viscosity modifier1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

4 skin studies and 3 eye studies are on record.

Classed as low4

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 7 studies

Not classified
Skin Irritation · Screening
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) according to EU Method B.6 (Skin Sensitisation)
Not classified
Skin Sensitization · Screening
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to
Not classified
Eye Irritation · Screening
Category 6.4A (Category 2A)
Eye Irritation · Read Across