What is this ingredient?

미국 FDA 물질 등록 · UNII PA7O2U6S2Q · 등록명 METHOXYISOPROPYL ACETATE · 단일 화학물질

All ingredients

Ingredient Dictionary

METHOXYISOPROPYL ACETATE

How much products actually contain

No product states its amount yet.

Of the products containing it, 26 list it before the 1% line and 0 after it (usually 1% or less).

Products using this ingredient

12 of 26 confirmed · likeliest to carry enough first · See all 26

Definition

US FDA substance register · UNII PA7O2U6S2Q · registered name METHOXYISOPROPYL ACETATE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Base that dissolves other ingredientsSOLVENT

Safety & regulatory references

Canada

Maximum Concentration Permitted : 0.5% total of 2-methoxypropanol (1589-47-5) and/or 2-methoxypropyl-1-acetate (70657-70-4)

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

Reviewed by CIR: Final Report on the Safety Assessment of Methoxyisopropanol and Methoxyisopropyl Acetate as Used in Cosmetics

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name 酢酸メトキシイソプロピル: 本品は、次の化学式で表される有機化合物である。

Source: JCIA labelling names (Japan)

Names & identifiers

METHOXYISOPROPYL ACETATEINCI메톡시아이소프로필아세테이트Korean label name (MFDS standard)2-Propanol, 1-methoxy-, acetateSynonym酢酸メトキシイソプロピルJapanese labelling name

CAS No.chemical registry number: 108-65-6
CAS No.chemical registry number: 84540-57-8
EC No.EU chemical inventory number: 203-603-9
EC No.EU chemical inventory number: 283-152-2
DTXSIDUS EPA chemical ID: DTXSID1026796
DTXCIDUS EPA compound ID: DTXCID106796

IUPAC: 1-Methoxypropan-2-yl acetate
Molecular formula: C6H12O3
Molecular weight: 132.159 g/mol

Measured properties

Appearance: Propylene glycol methyl ether acetate is a colorless liquid with a sweet ether-like odor. (USCG, 1999) · Dry Powder, Large Crystals, CBI, Liquid
Odour: Sweet, ether-like
Boiling point: 302 °F at 760 mmHg (USCG, 1999) · 145-146 °C
Melting point: -66 °C
Solubility: In water, 1.98X10+5 mg/L at 25 °C · In water, 198 g/L at 20 °C, pH 6.8
Density: 0.969 at 68 °F (USCG, 1999) - Less dense than water, will float · 0.969 at 20 °C
Stability: Stable under recommended storage conditions.
Viscosity: 1.23 sq mm/sec at 20 °C
Colour: colourless
Melting/freezing point: &amp, lt, -87 ℃
Initial boiling point and range: 145~147 ℃
Flash point: 42 ℃
Upper/lower flammability or explosive limits: 10.8 / 1.5 %
Vapour pressure: 3.75 ㎜Hg
Water solubility: 19800 ㎎/ℓ (at 25℃)
Vapour density: 4.6
Relative density: 0.965 (0.965-0.967 at 20 ℃)
n-Octanol/water partition coefficient (Kow): 0.43
Auto-ignition temperature: 315 ℃
Molecular weight: 132.16

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 130 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Wetting agent (non-aqueous)36
UV stabilizer34
Solvent26
Processing aids not otherwise specified7
Dispersing agent3
Flow promoter3
Photosensitive agent3
Pigment2

12 other uses

Defoamer2
Intermediate2
Surface modifier2
Diluent2
Viscosity modifier1
Adhesion/cohesion promoter1
Coalescing agent1
Fragrance1
Plating agent1
Film former1
Sealant (barrier)1
Cleaning agent1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

7 skin studies and 4 eye studies are on record.

Classed as low8

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 11 studies

Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation)
Not classified
Skin Sensitization · Screening
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation)
Not likely to be sensitizing
skin sensitisation · Screening · according to other guideline: Maguire, H.C. (1973): The bioassay of contact allergens in the guinea pig. J. Soc. Cosmetic Chem., 24, 151-162.
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: Fed. Register 38: 187, Part 1500, Section 41, 1973. according to OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to
Not classified
Skin Irritation · Screening
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: Fed. Register 43: 163.81-4, 1978. according to
Category 2B
Eye Irritation · Screening
Category 6.4A (Category 2A)
Eye Irritation · Read Across