Ingredient Dictionary

METHYL ACETAMIDE

N-methylacetamide is a monocarboxylic acid amide that is the N-methyl derivative of acetamide.

Definition

N-methylacetamide is a monocarboxylic acid amide that is the N-methyl derivative of acetamide. It has a role as a metabolite. It is a member of acetamides and a monocarboxylic acid amide. It is functionally related to an acetamide.

Source: PubChem

US FDA substance register · UNII V0T777481M · registered name METHYL ACETAMIDE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

No declared roleNOT REPORTED

Safety & regulatory references

Banned: Argentina · ASEAN · Brazil · China · European Union · South Korea · Taiwan · United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)

Not classified under Korea’s toxic-substance GHS list · existing chemical substance · priority-management substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex II (prohibited substances), entry 745

Source: EU prohibited substances (Annex II)

Restriction II/745

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Names & identifiers

METHYL ACETAMIDEINCI메틸아세타마이드Korean label name (MFDS standard)Acetamide, N-methyl-Synonym

CAS No.chemical registry number: 79-16-3
EC No.EU chemical inventory number: 201-182-6
DTXSIDUS EPA chemical ID: DTXSID0047167
DTXCIDUS EPA compound ID: DTXCID8027167

IUPAC: N-Methylacetamide
Molecular formula: C3H7NO
Molecular weight: 73.095 g/mol

Measured properties

Appearance: Solid, mp = 28 deg C, [HSDB] White crystalline solid, mp = 26-28 deg C, [Alfa Aesar MSDS] · NEEDLES
Boiling point: 205 °C
Melting point: 28 °C
Solubility: SOL IN CHLOROFORM · Soluble in alcohol, ether, acetone, benzene
Density: 0.9371 @ 25 °C/4 °C
Viscosity: 3.65 centipose (30 °C), 3.23 centipose (35 °C), 3.012 centipose (40 °C) · 10.8 cP
Dissociation constant: pK(BH+, protonated base)= 1.25 @ 25 °C
Colour: white
Melting/freezing point: 28 ℃
Initial boiling point and range: 205 ℃
Flash point: 108 ℃
Upper/lower flammability or explosive limits: 18.1 / 3.2 %
Vapour pressure: 0.44 ㎜Hg (at 23℃)
Water solubility: 1000000 ㎎/ℓ (at 20℃)
Relative density: 0.9371 (at 25℃/4℃)
n-Octanol/water partition coefficient (Kow): -1.05
Auto-ignition temperature: 490 ℃
Molecular weight: 73.09

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

No specific technical function1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

3 skin studies and 2 eye studies are on record.

Classed as moderate1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 5 studies

Classification not possible
Skin Irritation · Screening
Classification not possible
Skin Sensitization · Screening
Moderate or Mild Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to
Classification not possible
Eye Irritation · Screening