Ingredient Dictionary

METHYL ACETOACETATE

Methylacetoacetic acid is an oxo carboxylic acid.

Definition

Methylacetoacetic acid is an oxo carboxylic acid.

Source: PubChem

US FDA substance register · UNII CW4I82QAX1 · registered name Methyl acetoacetate · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Gives the product a scentPERFUMING

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

More data — names, identifiers, properties, test records, literature

Names & identifiers

METHYL ACETOACETATEINCIButanoic acid, 3-oxo-, methyl esterSynonym

CAS No.chemical registry number: 105-45-3
EC No.EU chemical inventory number: 203-299-8
DTXSIDUS EPA chemical ID: DTXSID9026716
DTXCIDUS EPA compound ID: DTXCID706716

IUPAC: Methyl 3-oxobutanoate
Molecular formula: C5H8O3
Molecular weight: 116.116 g/mol

Measured properties

Appearance: liquid
Colour: Colorless
Odour: Agreeable odor
Melting/freezing point: -35 ℃
Initial boiling point and range: 166~173 ℃ (1013 hPa)
Flash point: 67 ℃
Vapour pressure: 0.133 ㎪(1.33 hPa at 28.5 deg c)
Water solubility: 460000 ㎎/ℓ(460 g/l at 20 deg c / pH : 4 at 110 g/l and 20 deg c)
Vapour density: 4.0 ((Air= 1))
Relative density: 1.0762 (1.0762 g/cu cm at 20 deg C)
n-Octanol/water partition coefficient (Kow): -0.69
Auto-ignition temperature: 280 ℃(at 1013 hPa)
Molecular weight: 116.11

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 10 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Processing aids not otherwise specified2
Fragrance2
Intermediate2
Cleaning agent1
Flavouring and nutrient1
Solvent1
Monomers1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

5 skin studies and 6 eye studies are on record.

Classed as low4

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 11 studies

Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
Classification not possible
Skin Sensitization · Screening
Not classified
Skin Irritation · Screening
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: DOT (Transport-Classification) Guidelines according to
Eye Irrit. 2
Eye Irritation · Authoritative
Severe Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Category 6.4A (Category 2A)
Eye Irritation · Read Across
Category 2
Eye Irritation · Screening
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to
Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to