Methyl butyrate is a fatty acid ester.
Definition
Methyl butyrate is a fatty acid ester.
Source: PubChem
US FDA substance register · UNII CGX598508O · registered name Methyl butyrate · single chemical substance
Cosmetic roles
Gives the product a scentPERFUMING
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Names & identifiers
METHYL BUTYRATEINCIButanoic acid, methyl esterSynonym
- CAS No.chemical registry number
- 623-42-7
- EC No.EU chemical inventory number
- 210-792-1
- DTXSIDUS EPA chemical ID
- DTXSID5047083
- DTXCIDUS EPA compound ID
- DTXCID3027083
- IUPAC
- Methyl butanoate
- Molecular formula
- C5H10O2
- Molecular weight
- 102.133 g/mol
Measured properties
- Appearance
- Methyl butyrate appears as a clear colorless liquid. Flash point 57 °F. Less dense than water and slightly soluble in water. Hence floats on water. Vapors heavier than air. · Liquid
- Odour
- APPLE-LIKE ODOR
- Boiling point
- 216 °F at 760 mmHg (NTP, 1992) · 102.8 °C @ 760 mm Hg
- Melting point
- -139 °F (NTP, 1992) · -85.8 °C
- Solubility
- 10 to 50 mg/mL at 72 °F (NTP, 1992) · Miscible in ethanol, ethyl ether, slightly soluble in carbon tetrachloride
- Density
- 0.8984 at 68 °F (USCG, 1999) - Less dense than water, will float · 0.8984 @ 20 °C/4 °C
- Colour
- colourless
- Melting/freezing point
- -84 ℃
- Initial boiling point and range
- 102 ℃
- Flash point
- 14 ℃
- Upper/lower flammability or explosive limits
- 8.8 / 1.6 %
- Vapour pressure
- 301 ㎜Hg
- Water solubility
- (1.7%)
- Vapour density
- 3.53
- Relative density
- 0.8984
- n-Octanol/water partition coefficient (Kow)
- 1.29
- Viscosity
- 0.54 cP
- Molecular weight
- 102.13
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 9 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Fragrance4
- Intermediate3
- Flavouring and nutrient2
Source: US EPA CompTox dashboard
Related literature
- Beta-Hydroxy-Beta-Methyl Butyrate (HMB) and 2-Hydroxy-Benzyl Amine (2-HOBA) for Treatment of Inflammatory Skin Conditions · 2025
- An open-label, randomized, controlled trial on the benefit of β-hydroxy-β-methyl butyrate, l-arginine, l-glutamine combination beverages and locomotion training as supportive care for the treatment of unresectable hepatocellular carcinoma using lenvatinib: A pilot study (HELLO study). · 2024
- Dwarf Interstocks Improve Aroma Quality of ‘Huahong’ Apple (Malus × domestica) · 2022
- β-Hydroxy-β-methyl Butyrate/L-Arginine/L-Glutamine Supplementation for Preventing Hand–Foot Skin Reaction in Sorafenib for Advanced Hepatocellular Carcinoma · 2018
- Mixture of Arginine, Glutamine, and &bgr;-hydroxy-&bgr;-methyl Butyrate Enhances the Healing of Ischemic Wounds in Rats · 2017
Linked databases 16
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
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