Methyl cinnamate is a methyl ester resulting from the formal condensation of methyl cinnamic acid with methanol.
定義
Methyl cinnamate is a methyl ester resulting from the formal condensation of methyl cinnamic acid with methanol. It is found naturally in the essential oils of Alpinia and Basil leaf oil, and widely used in the flavor and perfume industries. It has a role as an insect attractant, a volatile oil component, a flavouring agent, a fragrance and an anti-inflammatory agent. It is an alkyl cinnamate and a methyl ester.
出典: PubChem
米国FDA 物質登録 · UNII 533CV2ZCQL · 登録名 METHYL CINNAMATE · 単一の化学物質
化粧品での役割
安全性・規制情報
韓国の有害物質GHS分類なし · 既存化学物質
詳しい資料 — 表示名・識別番号・物性・試験記録・文献
別名・識別情報
- CAS No.化学物質登録番号
- 103-26-4
- EC No.EU化学物質目録番号
- 203-093-8
- DTXSID米国EPA化学物質番号
- DTXSID6042151
- DTXCID米国EPA化合物番号
- DTXCID5028118
- IUPAC
- Methyl 3-phenylprop-2-enoate
- 分子式
- C10H10O2
- 分子量
- 162.188 g/mol
測定された物性
- 性状
- Liquid · Solid with a fruity, balsamic odor like strawberries, mp = 36 deg C, [Merck Index] Light yellow crystals, mp = 36-38 deg C, [Sigma-Aldrich MSDS]
- 沸点
- 262-263 °C
- 溶解性
- insoluble in water, soluble in oils · moderately soluble (in ethanol)
- 融点・凝固点
- 31~38 ℃
- 初留点および沸点範囲
- 260~263 ℃
- 引火点
- &, gt, 110 ℃
- 蒸気圧
- 0.011 ㎜Hg (25 C)
- 比重
- 1.042 (at 36℃)
- n-オクタノール/水分配係数（Kow）
- 2.18
- 粘度
- 1.26 cP (100 C)
- 分子量
- 162.08
物質そのものを測定した値です。安全保健公団（KOSHA）の資料はSDS作成・確認の参考用で、原料商品の規格ではありません。
出典: PubChem · 韓国安全保健公団 SDS
製品が実際に使っている用途
米国EPAにこの成分を届け出た製品85件の用途です。化粧品以外の製品も含まれるため、上の数行がこの成分の主な使い道といえます。
- Fragrance80
- Flavouring and nutrient2
- Opacifer1
- Viscosity modifier1
- No specific technical function1
出典: 米国EPA CompTox
刺激・感作試験の記録
皮膚試験6件・眼試験1件の記録があります。
試験ごとに結論が分かれています（最も多い結論の割合 57%）。この成分が刺激性だとは言い切れないということです。 原料そのものを試験した記録で、完成品に含まれる濃度での刺激性とは異なります。
試験7件をすべて見る
- High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) 1981 Edition - High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline: Kero, M., and Hannuksela, M. (1980). Guinea pig maximisation test, open epicutaneous test, and chamber test in the induction of delayed contact hypersensitivity. Contact Derm. 6, 341-344. - High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation) - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to - High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline: Kelcak G. (1983) Identification of contact allergens: predictive tests in animals. In: Marzulli FN, Maibach HI, (eds), Dermatoxicology, 2nd Ed., Hemisphere Ney York, pp 193-236. - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to
出典: 米国EPA CompTox
関連文献
- Seasonal variation in Operculicarya decaryi H. Perrier essential oil composition in correlation with its wound healing potential · 2025
- Anti-Inflammatory Activity of Alpinia malaccensis (Burm. f.) Roscoe and Kaempferia galanga L. Rhizome Essential Oil Gel Formulations by Carrageenan Induction Method · 2022
- trans-Cinnamic acid, but not p-coumaric acid or methyl cinnamate, induces fibroblast migration through PKA- and p38-MAPK signalling pathways. · 2021
- Isolation and Characterization of Antioxidant Active Compounds from the Leaves and Flowers of Manilkara hexandra (Roxb.) · 2021
- Chemical Constituent Profiling of Phyllostachys heterocycla var. Pubescens with Selective Cytotoxic Polar Fraction through EGFR Inhibition in HepG2 Cells · 2021