Ingredient Dictionary

METHYL DI-T-BUTYL HYDROXYHYDROCINNAMATE

Benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, methyl ester is an alkylbenzene.

Definition

Benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, methyl ester is an alkylbenzene.

US FDA substance register · UNII 35RWF1ITXJ · registered name METHYL DI-T-BUTYL HYDROXYHYDROCINNAMATE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Gives the product a scentPERFUMINGSlows spoilage by oxygenANTIOXIDANT

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name ジ－ｔ－ブチルヒドロキシヒドロケイヒ酸メチル: 本品は、次の化学式で表される芳香族化合物である。

Source: JCIA labelling names (Japan)

Names & identifiers

METHYL DI-T-BUTYL HYDROXYHYDROCINNAMATEINCIBenzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, methyl esterSynonym메틸다이-t-부틸하이드록시하이드로신나메이트Korean label name (MFDS standard)ジ－ｔ－ブチルヒドロキシヒドロケイヒ酸メチルJapanese labelling name

CAS No.chemical registry number: 6386-38-5
EC No.EU chemical inventory number: 228-985-4
DTXSIDUS EPA chemical ID: DTXSID7027623
DTXCIDUS EPA compound ID: DTXCID707623

IUPAC: Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate
Molecular formula: C18H28O3
Molecular weight: 292.419 g/mol

Measured properties

Appearance: solid
pH: 5.8 (20℃)
Melting/freezing point: 66.1 ℃
Initial boiling point and range: 335.8 ℃(1013 hPa)
Vapour pressure: (0.00002 hPa (25℃))
Water solubility: 2.2 ㎎/ℓ
Vapour density: 10.1
Relative density: 0.925 (25℃)
n-Octanol/water partition coefficient (Kow): 5.5 (5.5-5.9)
Auto-ignition temperature: 370 ℃(1013 hPa)
Molecular weight: 292.42

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 15 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Fragrance6
Deodorizer4
Antioxidant3
Intermediate1
Reducing agent1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

4 skin studies and 4 eye studies are on record.

Classed as moderate1Classed as low2

The studies disagree (the most common conclusion covers 33%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 8 studies

Moderate or Mild Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to
Not classified
Skin Irritation · Screening
Classification not possible
Skin Sensitization · Screening
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: Proposed Guidelines of the United States Environmental Agency (EPA) s 163.81-5 "Primary dermal irritation study". Federal Register, Vol. 43, No. 163, August 22, 1978. according to
Not classified
Eye Irritation · Screening
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: Section 191.12 of the Final Order, Enforcement Regulations, Federal Register, Vol. 29. No. 182, P, 13009, 17 September 1964 according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: Proposed Guidelines of the United States Environmental Protection Agency (EPA) s 163.81-4 "Primary eye irritation study". Federal Register, Vol. 43, No. 163, August 22, 1978. according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to