Ingredient Dictionary

METHYL MORPHOLINE OXIDE

N-methylmorpholine N-oxide is a morpholine N-oxide resulting from the oxidation of the amino group of N-methylmorpholine.

Definition

N-methylmorpholine N-oxide is a morpholine N-oxide resulting from the oxidation of the amino group of N-methylmorpholine.

Source: PubChem

US FDA substance register · UNII ARC64PKJ0F · registered name METHYL MORPHOLINE OXIDE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Washes away surface impuritiesCLEANSINGBoosts latherSURFACTANT - FOAM BOOSTINGSurfactant that lifts dirtSURFACTANT - CLEANSING

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Names & identifiers

METHYL MORPHOLINE OXIDEINCI메틸모폴린옥사이드Korean label name (MFDS standard)Morpholine, 4-methyl-, 4-oxideSynonym

CAS No.chemical registry number: 7529-22-8
EC No.EU chemical inventory number: 231-391-8
DTXSIDUS EPA chemical ID: DTXSID3029287
DTXCIDUS EPA compound ID: DTXCID509287

IUPAC: 4-Methyl-4-oxo-1,4lambda~5~-oxazinane
Molecular formula: C5H11NO2
Molecular weight: 117.148 g/mol

Measured properties

Appearance: Liquid · White hygroscopic solid, [Merck Index] Light yellow crystalline solid, [Sigma-Aldrich MSDS]
Melting/freezing point: 75 ℃
Water solubility: 9.223+005E ㎎/ℓ ( at 25 deg C)
n-Octanol/water partition coefficient (Kow): -1.12
Molecular weight: 117.15

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 6 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Solvent1
Surfactant (surface active agent)1
Intermediate1
Foamant1
Cleaning agent1
Hydraulic fluids1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

2 skin studies and 1 eye studies are on record.

Classed as low4

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 3 studies

Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation)
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to