Ingredient Dictionary

METHYL N-METHYLANTHRANILATE

Methyl N-methylanthranilate is a methyl ester resulting from the formal condensation of the carboxy group of N-methylanthranilic acid with methanol.

Definition

Methyl N-methylanthranilate is a methyl ester resulting from the formal condensation of the carboxy group of N-methylanthranilic acid with methanol. It has a role as an animal metabolite, a plant metabolite and a fungal metabolite. It is a methyl ester, a benzoate ester, a substituted aniline and a secondary amino compound. It is functionally related to a N-methylanthranilic acid.

Source: PubChem

US FDA substance register · UNII 5Z37T562P9 · registered name DIMETHYL ANTHRANILATE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Methyl-N-methylanthranilate is a fragrance ingredient used in various cosmetics, including fine fragrances, shampoos, soaps and other toiletries as well as in non-cosmetic products such as household cleaners and detergents.

Cosmetic roles

Listed as a fragrance-composition material (not a claim that it adds scent)FRAGRANCE

Safety & regulatory references

Restricted: European Union · International fragrance standard (IFRA) · United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · Health Canada Cosmetic Ingredient Hotlist · IFRA fragrance standards · MFDS (Korea) cosmetic regulatory information · UK cosmetics regulations (OPSS)

ASEAN

Field of application and/or use : (a) Leave-on products (b) Rinse-off products
Maximum authorised concentration in the finished cosmetic product : (a) 0,1 % (b) 0,2 %
Other limitations and requirements : For (a): Not to be used in sunscreen products and products marketed for exposure to natural or artificial UV light. For (a) and (b): — Do not use with nitrosating agents — Maximum nitrosamine content: 50 μg/kg — Keep in nitrite-free containers

Canada

Maximum Concentration Permitted : 0.1%

유럽

Product Type, body parts : (a) Leave-on products (b) Rinse-off products
Maximum concentration in ready for use preparation : (a) 0,1 % (b) 0,2 %
Other : For (a): Not to be used in sunscreen products and products marketed for exposure to natural or artificial UV light. For (a) and (b): — Do not use with nitrosating agents — Maximum nitrosamine content: 50 μg/kg — Keep in nitrite-free containers

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex III (restricted substances), entry 323 · maximum concentration (a) 0,1 % (b) 0,2 % · applies to (a) Leave-on products (b) Rinse-off products

Source: EU restricted substances (Annex III)

Restriction Annex III/323 · SCCS opinion: Methyl-N-methylanthranilate Phototoxicity only; Opinion on Methyl-N-methylanthranilate (photo-toxicity only); Scientific Advice on the SCCS Opinion on methyl-N-methylanthranilate (MNM)(SCCS/1455/11).

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Names & identifiers

METHYL N-METHYLANTHRANILATEINCIBenzoic acid, 2-(methylamino)-, methyl esterSynonymMETHYL N-METHYL ANTHRANILATESynonym

CAS No.chemical registry number: 85-91-6
EC No.EU chemical inventory number: 201-642-6
DTXSIDUS EPA chemical ID: DTXSID1052581
DTXCIDUS EPA compound ID: DTXCID8031154

IUPAC: Methyl 2-(methylamino)benzoate
Molecular formula: C9H11NO2
Molecular weight: 165.192 g/mol

Measured properties

Appearance: Colorless or pale yellow liquid with an odor of grapes, [Hawley] Pale-yellow liquid with a slightly blue fluorescence or solid, Odor like orange peels, mp = 18.5-19.5 deg C, [HSDB] · Liquid
Odour: ORANGE & MANDARIN-PEEL-LIKE ODOR
Boiling point: 256 °C @ 760 MM HG · 255.00 to 256.00 °C. @ 760.00 mm Hg
Melting point: 18.5-19.5 °C · 19 °C
Solubility: INSOL IN WATER, SOL IN ALCOHOL, ETHER · SOL IN MOST COMMON ORGANIC SOLVENTS
Density: 1.120 @ 15 °C · 1.124-1.132
Melting/freezing point: 17 ℃(18.5~19.5℃(HSDB))
Initial boiling point and range: 258 ℃(256℃(HSDB))
Relative density: 1.120 (15℃)
Molecular weight: 165.19

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 59 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Fragrance56
Flavouring and nutrient3

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

4 skin studies and 2 eye studies are on record.

Classed as low7

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 6 studies

Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: as mentioned below according to
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline: as mentioned below
Category 6.3A (Category 2)
Skin Irritation · Read Across
Not likely to be sensitizing
skin sensitisation · Screening · according to other guideline: as mentioned below
Category 6.4A (Category 2A)
Eye Irritation · Read Across
Severe Irritation
eye irritation: in vivo · Screening · other guideline: as mentioned below equivalent or similar to