成分词典

METHYL N-METHYLANTHRANILATE

Methyl N-methylanthranilate is a methyl ester resulting from the formal condensation of the carboxy group of N-methylanthranilic acid with methanol.

定义

Methyl N-methylanthranilate is a methyl ester resulting from the formal condensation of the carboxy group of N-methylanthranilic acid with methanol. It has a role as an animal metabolite, a plant metabolite and a fungal metabolite. It is a methyl ester, a benzoate ester, a substituted aniline and a secondary amino compound. It is functionally related to a N-methylanthranilic acid.

来源: PubChem

美国FDA 物质登记 · UNII 5Z37T562P9 · 登记名称 DIMETHYL ANTHRANILATE · 单一化学物质

来源: 美国FDA 物质识别码（UNII）

Methyl-N-methylanthranilate is a fragrance ingredient used in various cosmetics, including fine fragrances, shampoos, soaps and other toiletries as well as in non-cosmetic products such as household cleaners and detergents.

化妆品中的作用

登记为香料组成物质（并非表示其增香）FRAGRANCE

安全与法规参考

限用: 国际香料标准（IFRA） · 欧盟 · 英国

来源: 东盟化妆品指令 · 欧盟化妆品法规 · 加拿大禁用·限用成分清单 · IFRA 香料标准 · 韩国食药处化妆品法规信息 · 英国化妆品法规

东盟

Field of application and/or use : (a) Leave-on products (b) Rinse-off products
Maximum authorised concentration in the finished cosmetic product : (a) 0,1 % (b) 0,2 %
Other limitations and requirements : For (a): Not to be used in sunscreen products and products marketed for exposure to natural or artificial UV light. For (a) and (b): — Do not use with nitrosating agents — Maximum nitrosamine content: 50 μg/kg — Keep in nitrite-free containers

加拿大

Maximum Concentration Permitted : 0.1%

유럽

Product Type, body parts : (a) Leave-on products (b) Rinse-off products
Maximum concentration in ready for use preparation : (a) 0,1 % (b) 0,2 %
Other : For (a): Not to be used in sunscreen products and products marketed for exposure to natural or artificial UV light. For (a) and (b): — Do not use with nitrosating agents — Maximum nitrosamine content: 50 μg/kg — Keep in nitrite-free containers

来源: 韩国食药处化妆品法规信息

未列入韩国有毒物质 GHS 分类 · 现有化学物质

来源: 韩国有毒物质 GHS 信息（环境公团）

欧盟化妆品法规附录III（限用物质）第323项 · 最高浓度 (a) 0,1 % (b) 0,2 % · 适用 (a) Leave-on products (b) Rinse-off products

来源: 欧盟限用成分（附录III）

Restriction Annex III/323 · SCCS opinion: Methyl-N-methylanthranilate Phototoxicity only; Opinion on Methyl-N-methylanthranilate (photo-toxicity only); Scientific Advice on the SCCS Opinion on methyl-N-methylanthranilate (MNM)(SCCS/1455/11).

来源: 欧盟 CosIng 成分清单

详细资料——标示名称、识别编号、物性、试验记录、文献

别名和识别信息

METHYL N-METHYLANTHRANILATEINCIBenzoic acid, 2-(methylamino)-, methyl ester同义名METHYL N-METHYL ANTHRANILATE同义名

CAS No.化学物质登记号: 85-91-6
EC No.欧盟化学品目录编号: 201-642-6
DTXSID美国EPA化学品编号: DTXSID1052581
DTXCID美国EPA化合物编号: DTXCID8031154

IUPAC: Methyl 2-(methylamino)benzoate
分子式: C9H11NO2
分子量: 165.192 g/mol

实测物性

性状: Colorless or pale yellow liquid with an odor of grapes, [Hawley] Pale-yellow liquid with a slightly blue fluorescence or solid, Odor like orange peels, mp = 18.5-19.5 deg C, [HSDB] · Liquid
气味: ORANGE & MANDARIN-PEEL-LIKE ODOR
沸点: 256 °C @ 760 MM HG · 255.00 to 256.00 °C. @ 760.00 mm Hg
熔点: 18.5-19.5 °C · 19 °C
溶解性: INSOL IN WATER, SOL IN ALCOHOL, ETHER · SOL IN MOST COMMON ORGANIC SOLVENTS
密度: 1.120 @ 15 °C · 1.124-1.132
熔点/凝固点: 17 ℃(18.5~19.5℃(HSDB))
初沸点和沸程: 258 ℃(256℃(HSDB))
比重: 1.120 (15℃)
分子量: 165.19

这是对物质本身测得的数值。韩国安全保健公团（KOSHA）的资料仅供编写和审核安全数据表参考，并非原料商品的规格。

来源: PubChem · 韩国安全保健公团安全数据表

产品实际使用的用途

这是向美国 EPA 申报含该成分的 59 款产品的用途。其中包括化妆品以外的产品，排在前几行的即为该成分的主要用途。

Fragrance56
Flavouring and nutrient3

来源: 美国EPA CompTox

刺激与致敏试验记录

记录有皮肤试验 4 项、眼部试验 2 项。

归类为低7 项

试验结论基本一致（100%）。这是对原料本身的试验记录，与成品中所含浓度下的刺激性不同。

查看全部 6 项试验

Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: as mentioned below according to
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline: as mentioned below
Category 6.3A (Category 2)
Skin Irritation · Read Across
Not likely to be sensitizing
skin sensitisation · Screening · according to other guideline: as mentioned below
Category 6.4A (Category 2A)
Eye Irritation · Read Across
Severe Irritation
eye irritation: in vivo · Screening · other guideline: as mentioned below equivalent or similar to