Ingredient Dictionary

METHYL PYRROLIDONE

N-Methylpyrrolidone can cause developmental toxicity according to The Environmental Protection Agency (EPA).

How much products actually contain

No product states its amount yet.

Of the products containing it, 1 list it before the 1% line and 1 after it (usually 1% or less).

Products using this ingredient

2 of 2 confirmed · likeliest to carry enough first

Definition

N-Methylpyrrolidone can cause developmental toxicity according to The Environmental Protection Agency (EPA).

Source: PubChem

US FDA substance register · UNII JR9CE63FPM · registered name Methylpyrrolidone · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Methyl Pyrrolidone is the substituted heterocyclic organic compound that conforms to the formula:

Cosmetic roles

Base that dissolves other ingredientsSOLVENT

Safety & regulatory references

Banned: ASEAN · European Union · United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · UK cosmetics regulations (OPSS)

Korea’s toxic-substance GHS classification: Danger · H315 (category 2) · H335 (category 3) · H360 (category 1B) · +1 more

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex II (prohibited substances), entry 1393

Source: EU prohibited substances (Annex II)

Restriction II/1393 · SCCS opinion: Opinion on N-Methyl-2-pyrrolidone NMP

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name メチルピロリドン: 本品は、次の化学式で表される複素環式化合物である。

Source: JCIA labelling names (Japan)

Names & identifiers

METHYL PYRROLIDONEINCI메틸피롤리돈Korean label name (MFDS standard)2-Pyrrolidinone, 1-methyl-SynonymメチルピロリドンJapanese labelling name

CAS No.chemical registry number: 51013-18-4
CAS No.chemical registry number: 872-50-4
EC No.EU chemical inventory number: 212-828-1
DTXSIDUS EPA chemical ID: DTXSID6020856
DTXCIDUS EPA compound ID: DTXCID60856

IUPAC: 1-Methylpyrrolidin-2-one
Molecular formula: C5H9NO
Molecular weight: 99.133 g/mol

Measured properties

Appearance: N-methyl-2-pyrrolidone appears as a clear colorless liquid with a "fishlike" odor. Denser than water. Flash point 199 °F. Contact may irritate skin, eyes and mucous membranes. May be toxic by ingestion. · Liquid, Other Solid, Dry Powder, CBI
Odour: Mild amine odor
Boiling point: 396 °F at 760 mmHg (NTP, 1992) · 202 °C at 760 mm Hg
Melting point: -9 °F (NTP, 1992) · -25 °C
Solubility: greater than or equal to 100 mg/mL at 68 °F (NTP, 1992) · Miscible with water, alcohol, ether, acetone, ethyl acetate, chloroform, benzene
Density: 1.03 at 77 °F (USCG, 1999) - Denser than water, will sink · 1.027 at 25 °C/25 °C
Stability: NMP shows unlimited shelf life in tightly closed containers, slight discoloration does not impair its quality.
Viscosity: 1.65 cP at 25 °C · 1.62 mm²/s at 25 °C
pH: pH = 7.7-8 · 7.7~8
Melting/freezing point: -24.2 ℃(1013 hPa)
Initial boiling point and range: 204.3 ℃
Flash point: 91 ℃
Evaporation rate: ≥ 0.06
Upper/lower flammability or explosive limits: 9.5 / 1.3 %
Vapour pressure: 0.32 hPa(20℃)
Water solubility: 1000 ㎎/ℓ(20℃)
Vapour density: 1.03
Relative density: 1.027 (25/25℃)
n-Octanol/water partition coefficient (Kow): -0.46 (log Pow, 25℃)
Auto-ignition temperature: 245 ℃(1013 hPa)
Decomposition temperature: ( 719 kcal/mol)
Molecular weight: 99.13

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 51 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Solvent23
Processing aids not otherwise specified10
Intermediate2
Semiconductor and photovoltaic agent2
Degradant/impurity (EPA)2
Film former2
Plating agent1
Solubility enhancer1

8 other uses

Pigment1
Diluent1
Binder1
Dye1
Cleaning agent1
Flow promoter1
UV stabilizer1
Insulators1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

7 skin studies and 6 eye studies are on record.

Classed as moderate1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 13 studies

Skin irritation - category 2
Skin Irritation · Screening
Category 2
Skin Irritation · Screening
Category 6.3A (Category 2)
Skin Irritation · Read Across
Category 6.3B (Category 3)
Skin Irritation · Read Across
Classification not possible
Skin Sensitization · Screening
Skin Irrit. 2
Skin Irritation · Authoritative
Moderate or Mild Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to
Eye irritation - category 2A
Eye Irritation · Screening
Category 2A
Eye Irritation · Screening
Category 6.4A (Category 2A)
Eye Irritation · Read Across
Serious eye damage/eye irritation - Category 2B
Eye Irritation · Screening
Eye Irrit. 2
Eye Irritation · Authoritative
Moderate or Mild Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to