Methyl Thioglycolate is the ester of methyl alcohol and Thioglycolic Acid.
定义
美国FDA 物质登记 · UNII O1608LA9EL · 登记名称 METHYL THIOGLYCOLATE · 单一化学物质
Methyl Thioglycolate is the ester of methyl alcohol and Thioglycolic Acid. It conforms to the formula:
化妆品中的作用
安全与法规参考
- 限用
- 中国
来源: 韩国食药处 化妆品法规信息
阿根廷 · 巴西
- Field of application and/or use : Products for straightening or waving hair: 1. General use 2. Professional use
- Maximum concentration permitted at final product : 1. 8% ready to use pH 6 to 9,5 2.11% ready to use pH 6 to 9.5 The percentages are calculated as thioglycolic acid
- Other limitations and requirements : 1) and 2) In the USAGE must consist obligatorily the following information: - May cause sensitization by skin contact. - Avoid contact with eyes. - In case of contact with eyes, rinse immediately and thoroughly with water and consult a doctor. - Wear suitable gloves
- Use conditions and warnings that must appear on the label : 1) and 2) Contains thioglycolate Follow the instructions Keep out of reach of children. For professional use only (if applicable)
东盟
- Field of application and/or use : Hair waving or straightening products: 1. General use 2. Professional use
- Maximum authorised concentration in the finished cosmetic product : 1. 8% ready for use at pH 6-9.5 2. 11% ready for use at pH 6-9.5 Percentages calculated as thioglycolic acid.
- Other limitations and requirements : The directions for use drawn up in the national or official language(s) must obligatorily incorporate the following sentences: • May cause sensitisation in the event of skin contact. • Avoid contact with eyes. • In the event of contact with eyes, rinse immediately with plenty of water and seek medical advice. • Wear suitable gloves.
- Conditions of use and warning which must be printed on the labels : • Contains thioglycolate. • Follow the instructions. • Keep out of reach of children. • For professional use only.
欧盟
- Product Type, body parts : Hair waving or straightening products
- Maximum concentration in ready for use preparation : (a) 8% (b) 11% The abovementioned percentages are calculated as thioglycollic acid
- Other : (a) General use ready for use pH 6 to 9.5 (b) Professional use ready for use pH 6 to 9.5
- Wording of conditions of use and warnings : Conditions of use: (a) (b) May cause sensitization in the event of skin contact Avoid contact with eyes In the event of contact with eyes, rinse immediately with plenty of water and seek medical advice Wear suitable gloves Warnings: Contains thioglycolate Follow the instructions Keep out of reach of children (b) For professional use only
来源: 韩国食药处 化妆品法规信息
韩国有毒物质 GHS 分类: 危险 · H301 (第3类)
Restriction III/2b
来源: 欧盟 CosIng 成分清单
Reviewed by CIR: Final Amended Report on the Safety Assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl Thioglycolate, Glyceryl Thioglycolate, Isooctyl Thioglycolate, Isopropyl Thioglycolate, Magnesium Thioglycolate, Methyl Thioglycolate, Potassium Thioglycolate, Sodium Thioglycolate, and Thioglycolic Acid
来源: 美国CIR 安全性评估
详细资料——标示名称、识别编号、物性、试验记录、文献
别名和识别信息
- CAS No.化学物质登记号
- 2365-48-2
- EC No.欧盟化学品目录编号
- 219-121-7
- DTXSID美国EPA化学品编号
- DTXSID0033673
- DTXCID美国EPA化合物编号
- DTXCID8013673
- IUPAC
- Methyl sulfanylacetate
- 分子式
- C3H6O2S
- 分子量
- 106.14 g/mol
实测物性
- 性状
- Colorless liquid with a stench, [MSDSonline] · 液体
- 沸点
- 148 °C
- 解离常数
- pKa= 8.08 @ 25 °C
- 颜色
- 无色
- 熔点/凝固点
- -52.4 ℃
- 初沸点和沸程
- 148 ℃
- 蒸气压
- 3 ㎜Hg
- 溶解度
- 60070 ㎎/ℓ
- 蒸气密度
- 3.6641353123921303
- 正辛醇/水分配系数(Kow)
- 0.32
- 自燃温度
- 56 ℃
- 分子量
- 106.15
这是对物质本身测得的数值。韩国安全保健公团(KOSHA)的资料仅供编写和审核安全数据表参考,并非原料商品的规格。
来源: PubChem · 韩国安全保健公团 安全数据表
产品实际使用的用途
这是向美国 EPA 申报含该成分的 1 款产品的用途。其中包括化妆品以外的产品,排在前几行的即为该成分的主要用途。
- Hair waving or straightening (EPA)1
来源: 美国EPA CompTox
刺激与致敏试验记录
记录有皮肤试验 3 项、眼部试验 1 项。
试验结论基本一致(100%)。 这是对原料本身的试验记录,与成品中所含浓度下的刺激性不同。
查看全部 4 项试验
- SkinSens1
Skin Sensitization · QSAR Predicted - Category 6.5B (Category 1)
Skin Sensitization · Read Across - Category 6.3A (Category 2)
Skin Irritation · Read Across - Category 6.4A (Category 2A)
Eye Irritation · Read Across
来源: 美国EPA CompTox