Chloromethylisothiazolinone is a 1,2-thiazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom and a chlorine at C-5.
- Korean limit
- 0.0015%
How much products actually contain
No product states its amount yet.
Of the products containing it, 4 list it before the 1% line and 64 after it (usually 1% or less).
Products using this ingredient
12 of 68 confirmed · likeliest to carry enough first · See all 68
Paul MitchellPaul Mitchell Cream Rinse
philosophyphilosophy Oil-Free Salicylic Acid Acne Treatment Cleanser
Paul MitchellPaul Mitchell Hemp Restoring Shampoo & Body Wash
Paul MitchellPaul Mitchell Sheer Hydration Conditioner
Paul MitchellPaul Mitchell KeraTriplex Treatment
Paul MitchellPaul Mitchell Tea Tree Special Conditioner Aluminum Bottle
BevelBevel Bevel Sulfate-Free Conditioner
Mielle OrganicsMielle Organics Lavender & Lychee Scalp Soothing Conditioner
Paul MitchellPaul Mitchell Platinum Blonde Violet Shampoo
It's a 10It's a 10 It's a 10 Silk Express Miracle Conditioner
Paul MitchellPaul Mitchell Shampoo Two
It's a 10It's a 10 It's a 10 Miracle Daily Conditioner
Definition
US FDA substance register · UNII DEL7T5QRPN · registered name METHYLCHLOROISOTHIAZOLINONE · single chemical substance
Chloromethylisothiazolinone is a 1,2-thiazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom and a chlorine at C-5. It is a powerful biocide and preservative and is the major active ingredient in the commercial product KathonTM. It has a role as an antimicrobial agent, a xenobiotic and an environmental contaminant. It is an organochlorine compound and a member of 1,2-thiazoles. It is functionally related to a methylisothiazolinone.
Source: PubChem
Methylchloroisothiazolinone is the heterocyclic organic compound that conforms to the formula:
Cosmetic roles
Safety & regulatory references
- Restricted
- South Korea
Source: MFDS (Korea) cosmetic regulatory information
Argentina · Brazil
- Maximum concentration permitted at final product : 0.0015% (a mixture in proportions of 3: 1 5-Chloro-2-methyl- isothiazol-3 (2H) -one and 2- Methylisothiazol-3 (2H) -one)
ASEAN
- Maximum authorised concentration in the finished cosmetic product : 0.0015 % (of a mixture in the ratio 3:1 of 5-chloro- 2-methylisothiazol 3(2H)-one and 2-methylisothiazol-3(2H)-one)
- Other limitations and requirements : Rinse-off products
Canada
- Conditions of Use by product type : (a) Not permitted in leave-on products. (b) Rinse-off products Note: If MI is present in a formulation with Methylisothiazolinone / Methylchloroisothiazolinone (MI/MCI) in combination, the cumulative, total concentration of MI and MI/MCI may not exceed 0.0015%.
- Maximum Concentration Permitted : b) 0.0015%
China
- Maximum concentration : 0.0015%
European Union
- Product Type, body parts : rinse-off products
- Maximum concentration in ready for use preparation : 0.0015% (of a mixture in the ratio 3:1 of 5-Chloro-2-methyl-isothiazol-3(2H)-one and 2-Methylisothiazol-3(2H)-one
Source: MFDS (Korea) cosmetic regulatory information
Korea’s toxic-substance GHS classification: Danger · H400 (category 1) · H410 (category 1) · H314 (category 1B) · +4 more
Restriction V/39
Source: EU CosIng ingredient list
Reviewed by CIR: Final Report on the Safety Assessment of Methylisothiazolinone and Methylchloroisothiazolinone
Reviewed by CIR: Ammended Safety Assessment of Methylisothiazolinone and Methylchloroisothiazolinone as Used in Cosmetics
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name メチルクロロイソチアゾリノン: 本品は、次の化学式で表される複素環式化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 26172-55-4
- EC No.EU chemical inventory number
- 247-500-7
- DTXSIDUS EPA chemical ID
- DTXSID9034286
- DTXCIDUS EPA compound ID
- DTXCID7014286
- IUPAC
- 5-Chloro-2-methyl-1,2-thiazol-3(2H)-one
- Molecular formula
- C4H4ClNOS
- Molecular weight
- 149.59 g/mol
What products actually use it for
What the 598 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Preservative555
- Processing aids not otherwise specified33
- Biocide6
- Monomers1
- Surface modifier1
- Fragrance1
- Antioxidant1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
6 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 7 studies
- Category 8.2B (Category 1B)
Skin Irritation · Read Across - Skin sensitisation - category 1
Skin Sensitization · Screening - Skin corrosion - category 1B
Skin Irritation · Screening - Sh
Skin Sensitization · Authoritative - Category 6.5B (Category 1)
Skin Sensitization · Read Across - SkinSens1
Skin Sensitization · QSAR Predicted - Category 8.3A (Category 1)
Eye Irritation · Read Across
Source: US EPA CompTox dashboard
Related literature
- Allergic contact dermatitis caused by methylchloroisothiazolinone/methylisothiazolinone in a medical device · 2016
- Quantification of Methylisothiazolinone and Methylchloroisothiazolinone Preservatives by High-Performance Liquid Chromatography · 2023
- Amended Safety Assessment of Methylchloroisothiazolinone and Methylisothiazolinone as Used in Cosmetics · 2021
- Methylchloroisothiazolinone and/or methylisothiazolinone in cosmetic products—A market survey · 2018
- Determination of methylisothiazolinone and methylchloroisothiazolinone in cosmetic products by ultra high performance liquid chromatography with tandem mass spectrometry. · 2015
Linked databases 23
- ASEAN Cosmetic Directive
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- Health Canada Cosmetic Ingredient Hotlist
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English